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Pulmonary Cell News| ESC & iPSC News 12.29 July 26, 2017 | |
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TOP STORYDerivation of Ground-State Female ESCs Maintaining Gamete-Derived DNA Methylation Researchers showed that the derivation of female mouse ESCs in the presence of 2i (Mek1/2 and Gsk3β) and leukemia inhibitory factor (2i/L ESCs) results in a widespread loss of DNA methylation, including a massive erasure of genomic imprints. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Prolonged Mek1/2 Suppression Impairs the Developmental Potential of Embryonic Stem Cells The authors showed that prolonged culture of male mouse ESCs in two small molecule inhibitors (2i) in the presence of leukemia inhibitory factor (LIF)(2i/L) results in irreversible epigenetic and genomic changes that impair their developmental potential. Furthermore, they found that female ESCs cultured in conventional serum plus LIF medium phenocopy male ESCs cultured in 2i/L. [Nature] Abstract PRDM15 Safeguards Naive Pluripotency by Transcriptionally Regulating WNT and MAPK–ERK Signaling Zinc-finger sequence-specific chromatin factors have essential roles in embryonic development and cell fate decisions. Scientists characterized the transcriptional regulator PR-domain-containing protein 15 (PRDM15), which acts independently of PRDM14 to regulate the naive state of mouse ESCs. [Nat Genet] Abstract AIRE Is a Critical Spindle-Associated Protein in Embryonic Stem Cells Investigators showed that Autoimmune Regulator (Aire), a transcription coordinator involved in immune tolerance processes, is a critical spindle-associated protein in mouse ESCs. [eLife] Full Article Researchers examined the role of combinatorial extracellular matrix (ECM) proteins on endothelial differentiation systematically using an arrayed microscale platform. Human pluripotent stem cells were differentiated on the arrayed ECM microenvironments for five days. [Sci Rep] Full Article Nanotopographic Influence on the In Vitro Behavior of Induced Pluripotent Stem Cells The authors identified nanopatterns that influence the stemness and proliferation as well as the adhesive properties in iPSCs, and thereby the feasibility of applying these nano-features for regenerative medicine. [Tissue Eng Part A] Abstract Mesoderm Lineage 3D Tissue Constructs Are Produced at Large-Scale in a 3D Stem Cell Bioprocess Scientists developed a 3D-culture platform that could realize the large-scale production of mesoderm lineage tissue constructs from ESCs. ESCs were cultured using their previously established 3D-bioprocess platform which was amenable to mass-production of 3D ESC-based tissue constructs. [Biotechnol J] Abstract Functional Analysis of the Promoters of the Small GTPases RhoA and RhoB in Embryonic Stem Cells Researchers performed a functional analysis of the promoters of the RhoA and the RhoB genes in order to identify regulatory elements that are important for their transcriptional control in ESCs. [Biochem Biophys Res Commun] Abstract Taking into account the significant role of retinoic acid (RA) during in vivo gametogenesis, scientists investigated the effects of its stimulation on directing the differentiation of ESCs into germ cells. The effects of RA was analyzed across dose-and-time upon various stages of gametogenesis like primordial germ cell induction, meiosis initiation and completion, haploid cell formation and development of the final gamete (oocyte and spermatozoa). [Gene] Abstract | |
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REVIEWSOsteosarcoma: Molecular Pathogenesis and iPSC Modeling Patient-derived iPSCs have been successfully utilized to model Li–Fraumeni syndrome-associated bone malignancy, demonstrating that iPSCs can serve as an in vitro disease model to elucidate osteosarcoma etiology. The authors provide an overview of osteosarcoma predisposition syndromes and review recently established iPSC disease models for these familial syndromes. [Trends Mol Med] Abstract Scientists summarize the current status of induced pluripotent stem cell–derived endothelial cells for modeling endothelial dysfunction associated with insulin resistance and discuss the challenges to overcoming these limitations. [Arterioscler Thromb Vasc Biol] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSLorenz Studer Awarded the 2017 Ogawa-Yamanaka Stem Cell Prize Lorenz P. Studer, MD, was announced as the winner of the 2017 Ogawa-Yamanaka Stem Cell Prize by the Gladstone Institutes. Studer is the director of the Center for Stem Cell Biology and a member of the Developmental Biology Program at the Memorial Sloan Kettering Cancer Center. [Gladstone Institutes] Press Release BioTime, Inc. announced that the Data Safety Monitoring Board (DSMB) has authorized the Company to move forward with enrollment for cohort three. [BioTime, Inc.] Press Release | |
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POLICY NEWSDing, Ding, Ding! CRISPR Patent Fight Enters Next Round The University of California has fired another legal salvo in the prolonged patent battle over CRISPR, the revolutionary gene-editing technology that has spawned a billion dollar industry. [ScienceInsider] Editorial Senate Spending Panel Would Squeeze Science Agencies but Exceed Trump Request A Senate spending panel voted today to reduce funding in 2018 below current levels for several science agencies under its jurisdiction. [ScienceInsider] Editorial Budding UK Innovation Agency Gains Cash — and Clout UK scientists fearful for their research funds ahead of Brexit were cheered when the government announced it would plough an extra £4.7 billion (US$6.1 billion) into research and development by 2020–21. But the biggest winner from the largely industry-focused cash may be a government innovation agency that is rapidly gaining clout. [Nature News] Editorial
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EVENTSNEW CiRA 2017 International Symposium – A Decade of Human iPSCs: From Bench to Bedside Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Post-Doctoral/PhD Position – Stem Cell Biology & Metabolism (University of Freiburg) NEW PhD Studentship – Cell Differentiation Programs (Cardiff University) Junior Principal Investigator – Molecular Oncology (FIRC Institute of Molecular Oncology) Assistant Professor – Stem Cell and Regenerative Biology (Harvard University) Doctoral Grant – 3D Culture of Pluripotent Stem Cell-Derived Brain Organoids (University of Antwerp) Postdoctoral Fellow – Stem Cell Tissue Engineering (Stanford University) Senior/Principal Scientist – Stem Cell Research (Plasticell Ltd) Laboratory Research Technician – Epigenetics of Stem Cells (Albert Einstein College of Medicine) Postdoctoral Position – Epigenetics of Pluripotent Stem Cells (Albert Einstein College of Medicine) Postdoctoral Fellow – Multiple Areas (University of Oklahoma) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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