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Pulmonary Cell News| ESC & iPSC News 13.20 May 23, 2018 | |
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TOP STORYA First Look at the Earliest Decisions that Shape a Human Embryo New research illuminates the molecular circuitry that determines a cell’s fate. The authors established a new platform for studying the earliest stages of human development and it could lead to novel treatments for a wide range of ailments. [Press release from The Rockefeller University discussing online prepublication in Nature] Press Release | Abstract | Editorial | News and Views | |
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PUBLICATIONS(Ranked by impact factor of the journal)Activity-Dependent Neuroprotective Protein Recruits HP1 and CHD4 to Control Lineage-Specifying Genes Scientists showed that activity-dependent neuroprotective protein (ADNP) interacts with the chromatin remodeller CHD4 and the chromatin architectural protein HP1 to form a stable complex, which they refer to as ChAHP. Besides mediating complex assembly, ADNP recognized DNA motifs that specify binding of ChAHP to euchromatin. [Nature] Abstract | News and Views Mechanics-Guided Embryonic Patterning of Neuroectoderm Tissue from Human Pluripotent Stem Cells Investigators report a micropatterned human pluripotent stem-cell-based neuroectoderm developmental model, in which pre-patterned geometrical confinement induces emergent patterning of neuroepithelial and neural plate border cells, mimicking neuroectoderm regionalization during early neurulation in vivo. [Nat Mater] Abstract | Press Release Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells Using single-pore detection and average nuclear envelope-fluorescence intensity, researchers found that Nup133 is dispensable for interphase and postmitotic nuclear pore complex scaffold assembly in pluripotent mouse ESCs. [Cell Rep] Full Article | Graphical Abstract To determine whether substates impact fate decisions of human ESCs (hESCs), the authors used a GFP reporter line to investigate the properties of fractions of putative undifferentiated cells defined by their differential expression of the endoderm transcription factor, GATA6, together with the hESC surface marker, SSEA3. [Stem Cell Reports] Full Article | Graphical Abstract Dual inhibition of the signaling kinases GSK3 and MEK (2i) converts ESC cultures into a state with more uniform and high Nanog expression. Scientists used continuous time-lapse imaging to quantify the dynamics of death, proliferation, and Nanog expression in mouse ESCs after 2i addition. [Stem Cell Reports] Full Article | Graphical Abstract The authors investigated the functional role of the WD-domain protein STRAP (serine threonine kinase receptor-associated protein) in the pluripotency and lineage commitment of murine ESCs. They generated Strap knockout mouse ESCs and subjected them to spontaneous differentiation. [Stem Cells] Abstract Endogenous Authentic OCT4A Proteins Directly Regulate FOS/AP-1 Transcription in Somatic Cancer Cells Scientists provide unequivocal evidence that full-length authentic OCT4A transcripts and proteins were both present in somatic cancer cells, and OCT4A proteins were heterogeneously expressed in the whole cell population and when expressed, they are predominantly localized in cell nucleus. [Cell Death Dis] Full Article The authors demonstrated a novel method to prepare feeder cells with high efficiency, timesaving, and low costs. Mouse embryonic fibroblasts in 3 × 104 cell/cm2 were fixed by methanol for 5 mins and air drying for 5 mins. [Sci Rep] Full Article To elucidate molecular mechanisms underlying phenotypes, scientists differentiated human isogenic disomic and trisomic pluripotent cells, and observed that trisomic cells showed defects in B cell, but not T cell differentiation. [Sci Rep] Full Article | |
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REVIEWSDrug Screening for Human Genetic Diseases Using iPSC Models The authors review the foundational technologies that have enabled iPSCs, the power and limitations of iPSC-based compound screens along with screening guidelines, and recent examples of screening efforts. [Hum Mol Genet] Abstract Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field. | |
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INDUSTRY NEWSTEDCO Announces $7.1 Million in New Stem Cell Program Awards The Maryland Stem Cell Research Commission has approved funding for 25 awards for a total of $7,140,901. [TEDCO] Press Release Kyoto University to Start Providing Embryonic Stem Cells for Clinical Studies Kyoto University said it will start providing human embryonic stem cells to colleges and private companies for clinical trials. [Kyoto University (Nikkei Inc.)] Press Release | |
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POLICY NEWSPM Will Pay to Have ‘Full Association’ with EU Research The Prime Minister (PM) made the strongest commitment yet to “fully associate” the UK with the EU’s £68bn research program post-Brexit. Theresa May said the UK would be willing to make “an appropriate contribution” and in return it would expect a “suitable level of influence”. [BBC News] Editorial Indonesian Plan to Clamp Down on Foreign Scientists Draws Protest The government’s proposals include stricter rules, and tougher penalties for researchers who break existing ones. [Nature News] Editorial Chief Academic Officer Accused in Ongoing Research Scandal at UCL Prominent geneticist David Latchman, the chief academic and administrative officer of Birkbeck, University of London (UCL), has been accused of “recklessness” for his role in an ongoing research scandal, according to a report described by The Telegraph. [The Scientist] Editorial Head of Controversial Agency Becomes Russian Minister for Science and Higher Education In a major restructuring, the Russian government has decided to split its Ministry of Education and Science here into two new departments: the Ministry of Education, responsible for primary and secondary education, and a new, separate Ministry for Science and Higher Education. [ScienceInsider] Editorial
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EVENTSNEW LabRoots: 2nd Annual Cell Biology Virtual Event Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESResearch Technologist – Stem Cell Biology (STEMCELL Technologies Inc.) Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.) Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.) Postdoctoral Fellow – hiPSC Based Cardiac Regeneration (Duke University) Postdoctoral Fellow – Human Skeletal Muscle Disease Modeling and Regeneration (Duke University) PhD Candidate Position – Cardiovascular Diseases and iPSCs (University Medical Center Göttingen) Scientist/Senior Scientist – Bioprocess Engineering (Bluerock Therapeutics, LLC.) Postdoctoral Fellow – Cardiovascular Tissue Engineering (Stanford University) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Postdoctoral Fellow – Stem Cells, Development and Cancer (Albert Einstein College of Medicine) Postdoctoral Associate – hiPSC-Based Brain Organoids (Rutgers University) Postdoctoral Fellow – Stem Cell Biology (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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