 | | Vol. 15.29 – 5 August, 2020 |
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| Scientists mapped the essential genes for the differentiation of human PSCs into the three germ layers by using a genome-wide loss-of-function library established in haploid human PSCs.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators studied a family affected by dilated cardiomyopathy (DCM) due to a frameshift variant in LMNA. Human iPSC–derived endothelial cells were generated from patients with LMNA-related DCM and phenotypically characterized.
[Science Translational Medicine] |
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| Scientists showed that BAP1 was dependent on the ASXL proteins and FOXK1/2 in facilitating gene activation across the genome. Although PR-DUB previously was shown to cooperate with PRC2, they observed minimal overlap and functional interaction between BAP1 and PRC2 in embryonic stem cells.
[Genome Research] |
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| CRISPR-Cas9 technology deleted PKD1 in human induced pluripotent stem cell and the cells induced to differentiate along pathways leading to formation of either nephron progenitor or uteric bud organoids.
[Journal of the American Society of Nephrology] |
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| Investigators showed that the protein kinase D inhibitor CID755673 was able to maintain the undifferentiated state of mouse ESCs in combination with the mitogen-activated protein kinase kinase inhibitor.
[Development] |
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| The authors developed iPSCs from secondary progressive multiple sclerosis (SPMS)-affected donors and age-matched controls (CT). They confirmed their efficient and similar oligoprogenitor (OPC) differentiation capacity, although they reported SPMS-OPCs were transcriptionally distinguishable from their CT counterparts.
[Cells] |
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| Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
[Oncogenesis] |
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| To culture PSCs on feeder cell layers, the elimination of feeder cells is required for biological or gene analysis and for cell passage. Therefore, a simple and cost-effective cell sorting technology is required. The authors focused on dielectrophoresis phenomena for cell separation because these do not require any fluorescent or magnetic dyes or antibodies.
[Micromachines] |
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| Researchers measured three pertinent variables in human embryonic stem (hES) cells as a model for the inner cell masses of human blastocysts. They found that RNA encoding the alpha-aminoadipic semialdehyde synthase enzyme, which regulates glutamate production from lysine, was highly expressed in hES cells.
[International Journal of Environmental Research and Public Health] |
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| iPSC cells are laboratory-produced cells that combine the biological advantages of somatic adult and stem cells for cell-based therapy. The reprogramming of cells, such as fibroblasts, to an ESC-like state is done by the ectopic expression of transcription factors responsible for generating embryonic stem cell properties.
[International Journal of Molecular Sciences] |
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| Researchers compile the literature describing recent advances in research on dedifferentiation, with an emphasis on tissue-specific findings, cellular mechanisms, and potential therapeutic applications.
[NPJ Regenerative Medicine] |
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| Research advocates were eager to learn who Health and Human Services Secretary Alex Azar would appoint to the board and to see its ideological makeup. On July 31st they got their first look as it gathered online for a one-time meeting run by the National Institutes of Health.
[ScienceInsider] |
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| Cynata Therapeutics Ltd. has announced positive results from the two-year follow-up of patients enrolled in the Phase I clinical trial of CYP-001, Cynata’s lead iPSC-derived Cymerus™ mesenchymal stem cell product.
[Cynata Therapeutics Inc.] |
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| Calidi Biotherapeutics, Inc., announced that the Investigational New Drug application submitted by its partner, Personalized Stem Cells, Inc. They have received FDA approval for the treatment of COVID-19 and pneumonia patients using stem cell therapy.
[Calidi Biotherapeutics, Inc.] |
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| October 26 – October 28
Virtual |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Institute of Molecular Biology – Mainz, Germany |
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| | Oklahoma Medical Research Foundation (OMRF) – Oklahoma City, Oklahoma, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | University of Connecticut Health – Farmington, Connecticut, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
