 | | Vol. 15.35 – 16 September, 2020 |
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| Scientists reconstructed molecular reprogramming trajectories of human dermal fibroblasts using single-cell transcriptomics. This revealed that reprogramming into primed and naive pluripotency followed diverging and distinct trajectories.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The primary objective of this study was to assess the safety and tolerability of CYP-001 (iPSC-derived MSCs), while the secondary objectives were to evaluate efficacy based on the proportion of participants who showed a complete response, overall response and overall survival by days 28/100.
[Nature Medicine] |
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| The polygenic risk score predicted the susceptibility to drug-induced liver injury in patients treated with fasiglifam, amoxicillin–clavulanate or flucloxacillin and in primary hepatocytes and stem cell-derived organoids from multiple donors treated with over ten different drugs.
[Nature Medicine] |
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| Scientists demonstrated that overexpression of microRNA let-7a or incubation with let-7g–enriched extracellular vesicles from endometrial epithelial cells prolonged the in vitro survival of mouse blastocysts, which developed into live pups after having been transferred to foster mothers.
[Science Advances] |
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| Human cerebral organoids revealed a change from weak to strong UBE3A in neuronal nuclei within three weeks of culture. Angelman syndrome human induced pluripotent stem cell-derived organoids also exhibited early silencing of paternal UBE3A, with topoisomerase inhibitors partially rescuing UBE3A levels and calcium transient phenotypes.
[Stem Cell Reports] |
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| The authors established iPSCs from patients with Shwachman–Diamond syndrome and analyzed their in vitro hematopoietic and endothelial differentiation potentials.
[Scientific Reports] |
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| Investigators used a human iPSC-derived striatal GABA neuron system to investigate the effects of ketamine on histone deacetylase 6 (HDAC6) and the morphological development of medium spiny neurons.
[Acta Pharmacologica Sinica] |
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| Vascular networks were generated from endothelial cells (ECs) derived from human iPSCs. Network formation by iPSC-ECs within fibrin gels was investigated in a mesenchymal stem cell co-culture spheroid model.
[Tissue Engineering] |
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| Researchers investigated the ability of nicotinamide to promote the development of mature catecholaminergic neuronal populations (associated with Parkinson’s disease) from mouse ESCs, as well as investigating the underlying mechanisms of nicotinamide’s action.
[PLoS One] |
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| The authors present the requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes towards applications to tissue engineering (TE) hearts. Electrospinning is an attractive fabrication method for cardiac TE scaffolds because it produces fibers that demonstrate the optimal potential for mimicking the complex structure of the cardiac extracellular matrix.
[Bioengineering] |
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| Century Therapeutics, developer of iPSC-derived allogeneic cell therapies for cancer, has announced the appointment of Michael C. Diem, MD, as Chief Business Officer. Dr. Diem has more than 15 years of experience in the global pharmaceutical and biotech industries and nearly 10 years of experience in academic and clinical medicine.
[Century Therapeutics (Business Wire, Inc.)] |
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| Curi Bio has announced the ComboMat™ platform, a proprietary human iPSC-derived cardiomyocyte maturation technology. Curi’s ComboMat platform leverages a combination of cues—including a proprietary microRNA cocktail—to drive the functional development and maturation of cardiomyocytes with applications in drug discovery, disease modeling, and safety and efficacy screening.
[Curi Bio] |
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| | The University of Georgia – Athens, Georgia, United States |
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| | Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine – Guangzhou, China or Maine, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | University of Saskatchewan – Saskatoon, Saskatchewan, Canada |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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