 | | Vol. 15.39 – 14 October, 2020 |
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| Investigators used human PSC-derived brain organoids to examine SARS-CoV-2 neurotropism. They found expression of viral receptor ACE2 in mature choroid plexus cells expressing abundant lipoproteins, but not in neurons or other cell types.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists postulate that exit from pluripotency involves intermediates that retain pluripotency while simultaneously exhibiting lineage-bias.
[Nature Communications] |
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| On one side, JMJD3 induced the pro-senescence factor Ink4a and degraded the pluripotency regulator PHF20 in a reprogramming factor-independent manner. On the other side, JMJD3 was specifically recruited by KLF4 to reduce H3K27me3 at both enhancers and promoters of epithelial and pluripotency genes.
[Nature Communications] |
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| Researchers optimized a culturing protocol capable of efficiently generating small human cerebral organoids derived from human (h)ESCs and hiPSCs.
[Molecular Psychiatry] |
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| The authors investigated the early transcriptional events of cellular reprogramming triggered by the co‐expression of Oct4, Sox2, Klf4, and c‐Myc in mouse embryonic fibroblasts and mouse hepatocytes.
[EMBO Journal] |
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| Scientists performed the largest single-cell transcriptomic study of human iPSC-derived dopaminergic neurons to elucidate gene expression dynamics in response to cytotoxic and genetic stressors.
[Cell Reports] |
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| Using embryos and ESC aggregates of different size, investigators showed that while pro-amniotic cavity formation in normal-sized embryos is achieved through basement membrane-induced polarization and exocytosis, cavity formation of increased-size embryos is delayed and achieved through apoptosis of cells that lack contact with the basement membrane.
[Stem Cell Reports] |
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| Modeling binge drinking using iPSC-derived human cerebral organoids, scientists sought to quantify the downstream toxic effects of alcohol (ethanol) on neural pathology phenotypes and signaling pathways within the organoids.
[Translational Psychiatry] |
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| For the first time, the authors report a highly controllable viral expression model based on an iPSC line from a healthy human donor.
[Scientific Reports] |
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| Scientists analyzed the applicability of a hydrojet-based method to deliver footprint-free iPSC-derived cardiomyocytes into the myocardium.
[Scientific Reports] |
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| Researchers investigated the role of Type 2 inositol 1,4,5-trisphosphate receptor (IP3R2) in the differentiation of human (h)ESCs to cardiomyocytes and in the hESC-derived cardiomyocytes.
[Acta Pharmacologica Sinica] |
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| Investigators showed that FGF/ERK signaling determines the global Polycomb repressive complex 2 (PRC2) occupancy through regulating the expression of PRC2-recruting factor JARID2 in naïve murine ESCs.
[iScience] |
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| The neural crest (NC) is an ESC population that contributes to a greatly expanding list of derivatives ranging from neurons and glia of the peripheral nervous system, facial cartilage and bone, pigment cells of the skin to secretory cells of the endocrine system. Scientists focus on what is specifically known about establishment and maintenance of NC stemness and ultimate fate commitment mechanisms.
[Stem Cells] |
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| The authors propose that advancement in kidney organoid research will be facilitated through increasing knowledge on nephrogenesis and combining promising techniques such as organ-on-a-chip models.
[Journal of Molecular Medicine] |
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| Axol Biosciences added multi-electrode array (MEA) screening services for human-iPSC-derived cells to its service offering for preclinical drug discovery. The company said that its new MEA screening services optimize human iPSC-derived cell culture, while also providing electrophysiology acquisition and analysis from physiologically relevant human cell models.
[Axol Bioscience Ltd.] |
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| April 9 – April 14, 2021
Washington, DC, United States |
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| | Center for Vascular and Inflammatory Diseases – Baltimore, Maryland, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | F. Hoffmann-La Roche AG – Basel, Switzerland |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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