 | | Vol. 15.40 – 21 October, 2020 |
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| The authors employed dopaminergic neurons and microglia differentiated from patient-derived iPSCs carrying LRRK2 G2019S, the most common Parkinson’s disease-associated mutation.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Loss of H3.3 in mouse ESCs elicited a highly specific opening of interstitial heterochromatin with minimal effects on other silent or active regions of the genome.
[Nature Communications] |
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| Scientists investigated the expression and function of SRPK family members in human pluripotent stem cells and the brain. SRPK1, SRPK2, and RNF12 were expressed in human iPSCs, and quantitative total proteomic analysis confirmed the expression of these components and REX1.
[Developmental Cell] |
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| To define molecular mechanisms for the damaging cardiac outflow tract defects caused by GATA6 variants, scientists studied transcriptional and epigenetic responses to GATA6 loss of function and missense variants during cardiomyocyte differentiation of isogenic human iPSCs.
[eLife] |
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| The authors report a protocol that efficiently induced near synchronous rosette organization, even from human PSC-derived neural progenitor cell monolayers that do not generally exhibit rosette formation using previously existing protocols.
[Frontiers in Cell and Developmental Biology] |
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| Human-iPSC-derived cardiomyocytes (hiPSC-CMs) provide an excellent platform for potential clinical and research applications. Identifying abnormal Ca2+ transients is crucial for evaluating cardiomyocyte function. Investigators developed an analytical pipeline for automatic assessment of Ca2+ transient abnormality, by employing advanced machine learning methods together with an Analytical Algorithm.
[Scientific Reports] |
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| The authors questioned whether chromodomain helicase DNA binding protein 7(CHD7) promoted gene transcription in neural progenitor cells via changes in chromatin accessibility. They used Chd7 null ESCs derived from Chd7 mutant mouse blastocysts as a tool to investigate roles of CHD7 in neuronal and glial differentiation.
[Scientific Reports] |
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| Scientists used human iPSC-derived endothelial cells (hiPSC-ECs) and bulk- and single-cell RNA sequencing to study the effect of flow on the transcriptomic landscape of hiPSC-ECs and their heterogeneity.
[Frontiers in Physiology] |
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| Researchers challenged network modeling with time-resolved proteome, transcriptome and methylome measurements in iPSC-derived human 3D cardiac microtissues to elucidate adverse mechanisms of anthracycline cardiotoxicity measured with four different drugs.
[Communications Biology] |
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| The authors discuss the anatomical and functional benefit of grafted iPSC-progenitors over their brain counterparts, their use in disease modeling and the missing gaps that still prevent to study their biology in the most integrated way, and to translate iPSC-stem cell based therapy to the clinic.
[Seminars in Cell & Developmental Biology] |
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| Investigators summarize the basic characteristics of glial cells, with the focus on their classical functions, heterogeneity, and uniqueness in human species. They further review the findings from recent studies that use iPSC-derived glial cells for central nervous system disease modeling.
[Molecular and Cellular Neuroscience] |
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| Lineage Cell Therapeutics, Inc. and Cancer Research UK have announced encouraging preliminary results from an ongoing Phase I clinical study of VAC2 in non-small cell lung cancer (NSCLC). Produced from a pluripotent cell technology using a directed differentiation method, VAC2 has demonstrated remarkably potent induction of immune responses in all patients dosed to date.
[nan] |
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| April 11 – April 13, 2021
San Diego, California, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, Zhejiang, China |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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| | Center for Vascular and Inflammatory Diseases – Baltimore, Maryland, United States |
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