 | | Vol. 15.41 – 28 October, 2020 |
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| Using a model of chronic hypoxia-inducible factor 1a (HIF1a) accumulation in pluripotent stem cell-derived oligodendrocyte progenitors (OPCs), scientists demonstrated that HIF1a activated non-canonical targets to impair generation of oligodendrocytes from OPCs.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers generated developmental cortical interneurons — which are known to be affected in schizophrenia when matured — from iPSCs derived from healthy controls and individuals with schizophrenia and co-cultured them with or without activated microglia.
[Nature Neuroscience] |
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| Scientists describe a method to generate oligodendrocyte precursor cells from human PSCs in only ~20 days, which could subsequently myelinate neurons, both in vitro and in vivo.
[Nature Protocols] |
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| Investigators generated pericyte-like cells (PCs) from human (h)PSCs through the intermediate stage of the cranial neural crest (CNC) and revealed that the hPSC-CNC PCs expressed typical pericyte markers including PDGFRβ, CD146, NG2, CD13, Caldesmon, and Vimentin, and displayed distinct contractile properties, vasculogenic potential and endothelial barrier function.
[Nature Communications] |
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| To address whether differential signaling was associated with particular cell fates and states, researchers generated a targeted mouse line expressing an ERK-kinase translocation reporter that enabled live quantification of ERK activity at single-cell resolution.
[Developmental Cell] |
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| Scientists observed widespread DNA methylation loss in G9a depleted and catalytic mutant ESCs. Furthermore, they defined how G9a regulates chromatin accessibility, epigenetic modifications, and transcriptional silencing in both catalytic-dependent and -independent manners.
[Cell Reports] |
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| The authors investigated ten different control hiPSC-cardiomyocyte (CM) lines and analyzed function and suitability for drug screening. Five commercial and five academic hPSC-CM lines were casted in engineered heart tissue format.
[Stem Cell Reports] |
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| Researchers generated in vitro neurodevelopmental disorder models including human induced pluripotent stem cell based monolayer neuronal differentiation, 3D neuroepithelial bud, and 3D cerebral organoid to study fetal brain development and the potential neuropathological effects induced by the HSV-1 infections.
[Plos Pathogens] |
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| Investigators developed a novel high-throughput assay to quantify mitochondrial and neuronal toxicity in human dopaminergic neuron-containing cultures from iPSCs.
[Frontiers in Cell and Developmental Biology] |
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| Scientists developed a defined, animal origin-free (CD-AOF) medium to generate all iPSC-liver buds. They developed a CD-AOF medium for hepatocytes, endothelial cells, and stage-matched MSCs i.e., septum transversum mesenchyme, in 2D cultures.
[Scientific Reports] |
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| Researchers refined a previously generated G13513A mtDNA-targeted platinum transcription activator-like effector nuclease (G13513A-mpTALEN) to more efficiently manipulate mtDNA heteroplasmy in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)-iPSCs.
[Molecular Therapy-Methods & Clinical Development] |
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| The authors identified and isolated human iPSC-dopamine neurons with a TH-RFP reporter. Using liquid extraction surface analysis (LESA) coupled with high-resolution mass spectrometry they developed a high-throughput method for untargeted single cell lipid profiling.
[iScience] |
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| Stem cells can be induced to differentiate to corneal epithelial cells and used in treatment in corneal epithelium deficiency. Multipotent stem cells (MSCs) and pluripotent stem cells (ESCs and iPSCs) are promising cells to address the problem. Various protocols have been developed to induce differentiation of the stem cells into corneal epithelial cells.
[International Journal of Molecular Sciences] |
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| Investigators provide a concise update on the generation of iPSC-derived cardiomyocytes (CMs) and their application in personalized cardiac regenerative medicine. They also discuss the current limitations and challenges in the application of iPSC-derived CMs.
[Stem Cell Reviews and Reports] |
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| AgeX Therapeutics, Inc. and ImStem Biotechnology, Inc. announced that ImStem has obtained from AgeX a non-exclusive, royalty-bearing sublicense to use AgeX’s clinical-grade ESC line ESI-053 to derive ImStem’s investigational MSC product candidate IMS001 for development in COVID-19 as well as acute respiratory distress syndrome from other causes.
[AgeX Therapeutics] |
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| insitro has entered into a five-year discovery collaboration with Bristol Myers Squibb, focused on the discovery and development of novel therapies for the treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). They will apply their proprietary platform to create iPSC-derived disease models for ALS and FTD.
[insitro (Businesswire, Inc.)] |
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| November 11 – November 13
Virtual |
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| | National University of Ireland Galway – Galway, Ireland |
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| | University of California, San Diego- La Jolla, California, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, Zhejiang, China |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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| | Center for Vascular and Inflammatory Diseases – Baltimore, Maryland, United States |
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