 | | Vol. 15.43 – 18 November, 2020 |
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| The authors showed that mouse ESCs could be coaxed to robustly undergo fundamental steps of early heart organogenesis with an in vivo-like spatiotemporal fidelity.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To access human endocardial cells, investigators generated a human (h)PSC-derived endothelial population that displayed many characteristics of endocardium, including expression of the cohort of genes that identified this lineage in vivo, the capacity to induce a trabecular fate in immature cardiomyocytes in vitro, and the ability to undergo EMT.
[Cell Stem Cell] |
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| Scientists developed a robust and efficient manufacturing system for the differentiation and expansion of high-quality NK cells derived from iPSCs. iPSC-derived NK cells produced inflammatory cytokines and exerted strong cytotoxicity against an array of hematologic and solid tumors.
[Science Translational Medicine] |
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| Researchers discovered a small-molecule compound, which they named tryptolinamide, that activated mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs.
[Nature Chemical Biology] |
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| An epigenome-wide analysis of human (h)ESCs and MSCs revealed that growth differentiation factor 6, which is involved in bone formation, was the most upregulated gene associated with MSCs compared to hESCs.
[Bone Research] |
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| Scientists established a protocol for in vitro reconstitution of human prospermatogonial specification whereby human primordial germ cell-like cells differentiated from human iPSCs were further induced into M-prospermatogonia-like cells and T1 prospermatogonia-like cells using long-term cultured xenogeneic reconstituted testes.
[Nature Communications] |
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| The authors engineered patterned substrates that recapitulated the biophysical properties of the early embryo and mediated the self-organization of “gastrulation-like” nodes in cultured human ESCs.
[Developmental Cell] |
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| Scientists provide systematically characterized glycosphingolipid profiles and expression level of glycosyltransferase upon the conversion of human ESCs from primed to naïve state.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Culturing human i3Neurons and CRISPRi-i3Neuron-iPSCs, researchers characterized a distinct multisystem disorder caused by mutations affecting VPS4A and demonstrated that its normal function was required for multiple human developmental and cellular processes.
[American Journal of Human Genetics] |
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| iPSCs from healthy controls, familial amyotrophic lateral sclerosis (ALS), and sporadic ALS patients were differentiated toward spinal motor neurons, cortical neurons, and cardiomyocytes.
[Cell Death & Differentiation] |
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| Scientists revealed reduced reactivity of the astrocytic glial fibrillary acidic protein in the degenerated substantia nigra of PRKN-mutated patients, as well as in midbrain organoids generated from iPSCs reprogramed from PRKN-mutated patient fibroblasts.
[npj Parkinson’s Disease] |
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| Investigators demonstrated phenotypic differences in cardiomyocytes derived from isogenic human iPSC-cardiomyocytes genetically edited to harbor mutations either within the pore or tail region of the ion channel.
[Stem Cell Reports] |
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| Scientists discuss the use of high-throughput assays in human iPSC-based neurodevelopmental models to probe genetic risk in a cell-type- and patient-specific manner.
[Nature Neuroscience] |
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| The authors summarize the patient iPSC‐derived aortic cells that have been utilized to model aortic diseases in vitro.
[Stem Cells Translational Medicine] |
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| Proteintech and HebeCell announced their collaborative partnership to develop proprietary nanobody based chimeric antigen receptor technology for the development and commercialization of iPSC-derived natural killer cells, a promising cellular immunotherapy treatment for cancer and other diseases.
[Proteintech] |
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| July 22 – July 23, 2021
Berlin, Germany |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | Seattle Children’s Research Institute – Seattle, Washington, United States |
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| | Ncardia – Share Gosselies, Belgium |
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| | The Francis Crick Institute – London, England, United Kingdom |
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