 | | Vol. 15.46 – 9 December, 2020 |
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| To evaluate whether lymphatic endothelial cells (LECs) produce lymphoangiocrine signals that promote cardiomyocyte (CM) proliferation and survival, scientists cultured CMs derived from human iPSCs with LEC-conditioned medium obtained from culturing commercially available human dermal LECs.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers assembled region-specific brain organoids with cerebral cortical organoids in 3D cultures to form cortico-striatal assembloids. Using viral tracing and functional assays in intact or sliced assembloids, they showed that cortical neurons sent axonal projections into striatal organoids and formed synaptic connections.
[Nature Biotechnology] |
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| By modulating fibroblast growth factor, transforming growth factor β, and WNT pathways, scientists derived pluripotent stem cells from mice, horses, and humans that are permissive for direct primordial germ cell-like cell induction in vitro and are capable of contributing to intra- or inter-species chimeras in vivo.
[Cell Stem Cell] |
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| The authors demonstrated that Cas9-ribonucleoprotein-based genome editors can correct two distinct mutant alleles within a single human cell precisely. Gene-corrected cells in an iPSC model of Pompe disease expressed the corrected transcript from both corrected alleles, leading to enzymatic cross-correction of diseased cells.
[Nature Communications] |
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| To avoid confounding immune-mediated extrinsic effect, investigators used an immune-deficient mouse model to compare iPSC-derived oligodendroglia from multiple sclerosis and healthy donors following engraftment in the developing CNS.
[Science Advances] |
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| Scientists demonstrated that integrated analysis and engineering of gene regulatory networks in PSC-derived multilineage human liver organoids directed maturation and vascular morphogenesis in vitro.
[Cell Systems] |
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| While demonstrating the utility of human iPSCs derived from multiplex families to identify significant cell-specific gene network alterations in schizophrenia, the authors support a role for disruption of PI3K/GSK3 signaling as a risk factor for schizophrenia.
[Neuropsychopharmacology] |
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| Previously, scientists identified SET as a factor that is rapidly downregulated during ESC differentiation, suggesting a possible role in the maintenance of pluripotency. Here, they explored SET’s function in early differentiation.
[Stem Cell Reports] |
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| Brain organoids grown from human pluripotent stem cells self-organize into cytoarchitectures resembling the developing human brain. Investigators present the SCOUT pipeline for automated multiscale comparative analysis of intact cerebral organoids.
[Scientific Reports] |
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| The authors report the functional characterization of 88 BRCA2 variants, including several previously uncharacterized variants, using a well-established mouse ESC-based assay.
[npj Genomic Medicine] |
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| Scientists present a proposed blueprint for translational regenerative medicine. They offer principles to help guide the selection of cells and materials, present key in vivo imaging modalities, and argue that the host immune response should be considered throughout design and development.
[Science Translational Medicine] |
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| Cytovia Therapeutics announced that it plans to file with the FDA in 2021 an Investigational New Drug application and initiate clinical trials in hematological and solid tumors with its Universal iPSC NK cell therapy.
[Cytovia Therapeutics (GlobeNewswire, Inc.)] |
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| July 26 – July 27, 2021
Virtual |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Ncardia – Share Gosselies, Belgium |
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