 | | Vol. 16.00 – 6 January, 2021 |
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| Previous analysis of RNA sequencing data from human naive PSCs reported multiple point “mutations” in cancer-related genes and implicated selective culture conditions. Scientists observed, however, that those mutations were only present in co-cultures with mouse feeder cells.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers describe the first application of biochemically engineered ten-eleven translocation (TET) mutants that unlink 5-methylcytosine oxidation steps, examining their effects on somatic cell reprogramming.
[Molecular Cell] |
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| Investigators demonstrated that recessive NOS1AP variants impaired CDC42/DIAPH-dependent actin remodeling, causing aberrant organoid glomerulogenesis, and leading to a glomerulopathy in humans and mice.
[Science Advances] |
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| Scientists investigated the effects of acute CCCTC-binding factor (CTCF) loss on chromatin architecture and transcriptional programs in mouse ESCs undergoing differentiation to neural precursor cells.
[Nature Structural & Molecular Biology] |
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| The authors describe an innovative retinoblastoma (Rb) organoid model derived from human ESCs with a biallelic mutagenesis of the RB1 gene. They identified tumorigenic growth in the Rb organoids, as well as properties consistent with human primary Rb.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers presented methodologies using single-cell RNA (scRNA-seq) sequencing analysis to address limitations. By repeatedly differentiating and applying scRNA-seq to motor neurons from healthy, familial amyotrophic lateral sclerosis (ALS), sporadic ALS, and genome-edited iPSC lines across multiple patients, batches, and platforms, they accounted for genetic and experimental variability toward identifying unified and reproducible ALS signatures.
[Cell Systems] |
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| The authors report that the developing chicken embryo is a permissive host for human (h)PSCs, allowing analysis of the pluripotency potential of hPSCs.
[Stem Cell Reports] |
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| Investigators engineered the pseudomyogenic hemangioendothelioma chromosomal translocation into human iPSCs using CRISPR/Cas9 and differentiate these into endothelial cells.
[Cell Reports Medicine] |
| | The authors investigated whether transplantation of undifferentiated human iPSCs into the injured rat spinal cord was able to induce morphological and functional improvement.
[Scientific Reports] |
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| Researchers propose using human-iPSC-derived cardiomyocytes/cardiac-stromal progenitor cells and cardiac organoid cultures as innovative experimental model systems to mimic clinical treatment, resulting in reproducible data, and promote the identification of immunotherapy-induced biomarkers of both early and late cardiotoxicity.
[Cancers] |
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| The Association for Research in Vision and Ophthalmology (ARVO) announced Yohei Tomita, MD, PhD, has received the 2021 Bert M. Glaser, MD Award for Innovative Research in Retina, which recognizes an early-career investigator who has made a novel discovery that impacted the understanding and/or treatment of a retinal disease or condition. Tomita’s projects involve the development of several tools, including an instrument that can measure mitochondrial function using Raman spectroscopy, and a second instrument meant to examine mitochondrial function in pluripotent stem cells.
[Association for Research in Vision and Ophthalmology] |
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| Spinogenix, Inc. announced that it will be collaborating with Dr. Rita Sattler at the Barrow Neurological Institute and Dr. Justin Ichida at the USC Keck School of Medicine on a grant awarded from the US Department of Defense’s (DOD) Congressionally Directed Medical Research Programs to evaluate its lead development candidate in ALS. The DOD grant will be used to study the effects of Spinogenix’s lead compound in human iPSCs from patients with ALS and from healthy volunteers.
[Spinogenix, Inc. (GlobeNewswire, Inc.)] |
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| February 17 – 21, 2021
Virtual |
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| | University of Luxembourg – Belval, Luxembourg |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Lieber Institute for Brain Development – Baltimore, Maryland, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
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