 | | Vol. 16.01 – 13 January, 2021 |
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| Using an unbiased genome-scale CRISPR knockout screen in mouse ESCs, investigators identified m6A RNA methylation as a way to restrict endogenous retroviruses.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated using an ESC model that transient expression of the T-box transcription factor Eomesodermin governs haemogenic competency of extra-embryonic mesoderm.
[Nature Cell Biology] |
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| The authors report that FMRP deficiency resulted in hyperactivated nonsense-mediated mRNA decay in human SH-SY5Y neuroblastoma cells and fragile X syndrome fibroblast-derived iPSCs.
[Nature Cell Biology] |
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| Researchers showed that a recently identified autophagy enhancer (MSL-7) reduced human IAPP oligomer accumulation in human iPSC-derived β-cells and diminished oligomer-mediated apoptosis of β-cells.
[Nature Communications] |
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| Investigators took advantage of iPSCs to develop an induced human ulcerative colitis-derived organoid model and compared it with the induced human normal organoid model.
[Nature Communications] |
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| Scientists detailed an accurate, step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment.
[Nature Protocols] |
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| Investigators describe a protocol for the continuous patterning of hepatic, biliary and pancreatic structures from a 3D culture of human PSCs.
[Nature Protocols] |
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| Expression data from developmental and adult neurogenesis showed relative enrichment of Notch and γ-secretase expression in stem cells, whereas expression of APP and β-secretase was enriched in neurons.
[Cell Reports] |
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| The authors report a genome-wide loss-of-function screening that identified gene mutations that could significantly reduce the rate of self-diploidization in haploid ESCs.
[Stem Cell Reports] |
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| Investigators identified the role of retinal pigment epithelium (RPE) basement membrane proteins type IV collagen, laminin, and nidogen-1 in the maturation and functionality of human ESC-RPE after cryopreservation.
[Scientific Reports] |
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| The authors examine potential mechanisms for maintenance or shifts in heteroplasmy that occur in iPSCs generated by cellular reprogramming, and further discuss manipulations that can alter heteroplasmy to impact stem and differentiated cell performance.
[Trends in Cell Biology] |
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| Scientists advocate for a paradigm shift towards the application of human iPSC-derived systems for Alzheimer’s and Parkinson’s disease modeling and the development of improved human-based models in a dish for drug discovery and preclinical assessment of therapeutic targets.
[Molecular Therapy] |
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| BlueRock Therapeutics, in collaboration with Memorial Sloan Kettering Cancer Center, announced that the US FDA has cleared their Investigational New Drug application to proceed with a Phase I study in patients with advanced Parkinson’s disease (PD). This is the first trial in the US to study PSC-derived dopaminergic neurons in patients with PD.
[BlueRock Therapeutics (PR Newswire, Inc.)] |
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| February 3 – 23, 2021
Virtual |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | Fondazione Human Technopole – Milan, Italy |
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| | Columbia University Medical Center – New York, New York, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Luxembourg – Belval, Luxembourg |
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