ESC & iPSC News Volume 16.01 | Jan 13 2021

2021-13-1 | ESC 16.01

ESC & iPSC News by STEMCELL Technologies
Vol. 16.01 – 13 January, 2021

m6A RNA Methylation Regulates the Fate of Endogenous Retroviruses

Using an unbiased genome-scale CRISPR knockout screen in mouse ESCs, investigators identified m6A RNA methylation as a way to restrict endogenous retroviruses.


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T-Box Transcription Factor Eomesodermin Governs Hemogenic Competence of Yolk Sac Mesodermal Progenitors

Scientists demonstrated using an ESC model that transient expression of the T-box transcription factor Eomesodermin governs haemogenic competency of extra-embryonic mesoderm.
[Nature Cell Biology]


of the Fragile X Syndrome Protein FMRP Results in Misregulation of Nonsense-Mediated mRNA Decay

The authors report that FMRP deficiency resulted in hyperactivated nonsense-mediated mRNA decay in human SH-SY5Y neuroblastoma cells and fragile X syndrome fibroblast-derived iPSCs.
[Nature Cell Biology]


An Autophagy Enhancer Ameliorates Diabetes of Human IAPP-Transgenic
Mice through Clearance of Amyloidogenic Oligomer

Researchers showed that a recently identified autophagy enhancer (MSL-7) reduced human IAPP oligomer accumulation in human iPSC-derived β-cells and diminished oligomer-mediated apoptosis of β-cells.
[Nature Communications]

Full Article

Organoids Derived from Patients with Ulcerative Colitis Recapitulate Colitic Reactivity

Investigators took advantage of iPSCs to develop an induced human ulcerative colitis-derived organoid model and compared it with the induced human normal organoid model.
[Nature Communications]

Full Article

Human Microglia Transplanted into Mouse Brain to Study Human Disease

Scientists detailed an accurate, step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment.
[Nature Protocols]


Engineering Human Hepato-Biliary-Pancreatic Organoids from Pluripotent Stem Cells

Investigators describe a protocol for the continuous patterning of hepatic, biliary and pancreatic structures from a 3D culture of human PSCs.
[Nature Protocols]


Familial Alzheimer’s Disease Mutations in PSEN1
Lead to Premature Human Stem Cell Neurogenesis

Expression data from developmental and adult neurogenesis showed relative enrichment of Notch and γ-secretase expression in stem cells, whereas expression of APP and β-secretase was enriched in neurons.
[Cell Reports]

Full ArticleGraphical Abstract

A Genetic Screen Identifies Etl4-Deficiency
Capable of Stabilizing the Haploidy in Embryonic Stem Cells

The authors report a genome-wide loss-of-function screening that identified gene mutations that could significantly reduce the rate of self-diploidization in haploid ESCs.
[Stem Cell Reports]

Full ArticleGraphical Abstract

Surface Protein Coatings Affect the Barrier Properties and Calcium Signaling of hESC-RPE

Investigators identified the role of retinal pigment epithelium (RPE) basement membrane proteins type IV collagen, laminin, and nidogen-1 in the maturation and functionality of human ESC-RPE after cryopreservation.
[Scientific Reports]

Full Article

Andreas Kurtz spearheaded a global stem cell registry to make hPSC data more accessible. Watch the webinar.

Mitochondrial DNA Dynamics in Reprogramming to Pluripotency

The authors examine potential mechanisms for maintenance or shifts in heteroplasmy that occur in iPSCs generated by cellular reprogramming, and further discuss manipulations that can alter heteroplasmy to impact stem and differentiated cell performance.
[Trends in Cell Biology]

Full Article

Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models

Scientists advocate for a paradigm shift towards the application of human iPSC-derived systems for Alzheimer’s and Parkinson’s disease modeling and the development of improved human-based models in a dish for drug discovery and preclinical assessment of therapeutic targets.
[Molecular Therapy]

AbstractGraphical Abstract


BlueRock Therapeutics in Collaboration with Memorial Sloan Kettering Cancer Center Receives IND Clearance for DA01 in Parkinson’s Disease

BlueRock Therapeutics, in collaboration with Memorial Sloan Kettering Cancer Center, announced that the US FDA has cleared their Investigational New Drug application to proceed with a Phase I study in patients with advanced Parkinson’s disease (PD). This is the first trial in the US to study PSC-derived dopaminergic neurons in patients with PD.
[BlueRock Therapeutics (PR Newswire, Inc.)]

Press Release


ISSCR: Stem Cells and Global Sustainability

February 3 – 23, 2021

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Communities & Communications Specialist

STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada

Manager – FACS-Based Characterization

Fondazione Human Technopole – Milan, Italy

Postdoctoral Researcher – Mitochondria and Hematopoietic Stem Cell Biology

Columbia University Medical Center – New York, New York, United States

Scientist – Organoid Research at the Barrett Lab

Cedars-Sinai – Los Angeles, California, United States

Postdoctoral Researcher – Molecular and Functional Neurobiology

University of Luxembourg – Belval, Luxembourg

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