 | | Vol. 16.06 – 17 February, 2021 |
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| To investigate the functional importance of an amino acid change in humans, investigators reintroduced the archaic allele into human iPSCs using genome editing and then followed their neural development through cortical organoids.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To hasten treatment development, researchers established iPSC lines from patients with Christianson syndrome representing a mutational spectrum, as well as biologically related and isogenic control lines.
[Science Translational Medicine] |
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| To study the roles of DNAJC6 in Parkinson’s disease (PD) pathogenesis, scientists used human ESCs with CRISPR-Cas9-mediated gene editing. They showed that DNAJC6 mutations caused key PD pathologic features, i.e., midbrain-type dopamine neuron degeneration, pathologic α-synuclein aggregation, increase of intrinsic neuronal firing frequency, and mitochondrial and lysosomal dysfunctions in human midbrain-like organoid.
[Science Advances] |
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| The authors provided a detailed protocol for mass production of definitive endoderm from human PSCs in scalable and easy-to-handle suspension culture using a rotating Erlenmeyer flask or a sophisticated, fully controllable, 150ml stirred tank bioreactor.
[Nature Protocols] |
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| Scientists describe a broadly applicable framework for detecting on-target effects in genome-edited iPSC cells and organisms after non-homologous end joining-mediated and homology-directed repair-mediated editing.
[Nature Protocols] |
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| Researchers discuss a novel strategy for neuropsychiatric drug discovery which aims to address limitations by identifying disease-related functional responses in a variety of patient-derived cells, such as iPSC-derived neurons and organoids or peripheral blood mononuclear cells.
[Translational Psychiatry] |
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| Investigators identified a novel BODIPY-derived fluorescent probe, BDL-E5, which detects live human iPSCs at the early reprogramming stage.
[Stem Cell Research & Therapy] |
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| Matrin3 (MATR3) is involved in the differentiation of neural cells. The authors elucidated its critical functions in regulating pluripotent circuits in human iPSCs.
[iScience] |
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| Researchers demonstrated a simple and precise method to simultaneously generate iPSC lines with different gene dosages using paired Cas9 nickases.
[Communications Biology] |
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| Investigators successfully generated a double reporter system allowing for the isolation of both ventricular and atrial cardiomyocyte subtypes within a single human iPSC line.
[Scientific Reports] |
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| With a view towards harnessing the therapeutic potential of canine mesenchymal stromal cells (cMSCs) as modulators of inflammation and the immune response, and to avoid the issues of the variable quality and quantity of harvested cMSCs, scientists examined the immunomodulatory properties of cMSCs derived from canine iPSCs, and compared them to cMSCs harvested from adipose tissue and bone marrow.
[Scientific Reports] |
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| Human iPSCs have the potential to generate all cell types of a human body under 2D culture conditions or form organ like structures- organoids, under 3D culture conditions.
[Biophysical Journal] |
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| The author summarizes the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration.
[International Journal of Molecular Sciences] |
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| Cytovia Therapeutics, Inc., and Cellectis announced that they have entered into a strategic research and development collaboration to develop TALEN® gene-edited iPSC Natural Killer (NK) and Chimeric Antigen Receptor-NK cells.
[Cytovia Therapeutics, Inc] |
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| March 8 – 10, 2021
Virtual |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | NCCR AntiResist – Basel, Switzerland |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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