 | | Vol. 16.10 – 17 March, 2021 |
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| Scientists described the reprogramming of fibroblasts into in vitro three-dimensional models of the human blastocyst, termed iBlastoids.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed an effective three-dimensional culture strategy with successive lineage differentiation and self-organization to generate blastocyst-like structures in vitro.
[Nature] |
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| Scientists discovered evidence of lineage-specific selection on the hedgehog signaling pathway, including a human-specific sixfold down-regulation of EVC2, a key hedgehog gene.
[Nature Genetics] |
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| Researchers introduced a computer-guided design tool that combines a computational framework for prioritizing more efficient combinations of instructive factors of cellular conversions, called IRENE, with a transposon-based genomic integration system for efficient delivery.
[Nature Communications] |
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| Investigators analyzed the genome-wide binding profile for ZNF91 in human cells and found that ZNF91 interacted with the VNTR region of SINE-VNTR-Alu (SVA)s. Through CRISPR-Cas9-mediated deletion of ZNF91 in human embryonic stem cells, they established that loss of ZNF91 resulted in increased transcriptional activity of SVAs.
[Genome Research] |
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| Scientists applied a synthetic mRNA-driven strategy to generate neuronal precursors from hiPSCs. These neuronal precursors were transformed by the MYC oncogene combined with p53 loss-of-function to establish a MYC-driven medulloblastoma model recapitulating the histological and transcriptomic hallmarks of Group 3 medulloblastoma.
[Molecular Cancer Therapeutics] |
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| Reprogramming could reverse the abnormal proliferation, differentiation, and DNA methylation patterns of osteonecrosis of the femoral head-bone marrow-derived mesenchymal stem cells. Transplantation of iPSC-mesenchymal stem cells could effectively promote bone repair and angiogenesis in the necrosis area of the femoral head.
[Stem Cell Research & Therapy] |
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| Researchers established iPSCs from the peripheral blood of rhesus macaques (Rh-iPSCs) by combining the Yamanaka reprograming factors and two inhibitors and differentiated the cells into functional macrophages through hematopoietic progenitor cells.
[Molecular Therapy-Methods & Clinical Development] |
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| The authors previously developed a two-step protocol for differentiation of hiPSCs and showed that it could model both normal and abnormal trophoblast differentiation. Here, they applied this protocol to iPSCs derived from placentas of pregnancies with or without preeclampsia.
[Scientific Reports] |
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| Investigators showed that endogenous suppression of WNT signaling in hPSCs at the onset of differentiation prevented the switch from self-renewal to definitive endoderm specification.
[Scientific Reports] |
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| Understanding the origin of primordial germ cells in the peri-implantation embryo is crucial not only for accurate modeling of this essential process using stem cells, but also in determining the role of global epigenetic reprogramming upon which sex-specific differentiation into gametes relies.
[Development] |
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| For domestic animals, numerous attempts have been made to obtain PSCs and iPSCs. Even if the plasticity of the cells obtained is not always optimal, the recent progress in obtaining reprogrammed cells is encouraging.
[Veterinary Research] |
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| The South Korean government announced that it would spend 595 billion won ($525.6 million) by 2030 to support the country’s regenerative medicine sector.
[The Korea Herald] |
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| | Gladstone Institute – San Francisco, California, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | NCCR AntiResist – Basel, Switzerland |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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