 | | Vol. 16.13 – 7 April, 2021 |
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| Scientists identified a novel role of PUMA in regulation of DNA repair in embryonic or iPSCs and immortalized hematopoietic progenitor cells after ionizing radiation.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used mass spectrometry to describe the molecular events triggered by inhibition of Mek1/2 and Gsk3 and inhibition of Cdk8/19 on ESCs.
[Nature Communications] |
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| In cell lines derived from Parkinson’s disease patients, astrocytes were characterized by a significant decrease in S100B and GFAP-positive astrocytic profiles associated with marked decrease in astrocyte complexity.
[npj Parkinsons Disease] |
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| Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.
[Cell Death & Disease] |
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| To elucidate the underlying pathogenic mechanisms of myoclonus dystonia, researchers investigated iPSC-derived striatal medium spiny neurons from two myoclonus-dystonia patients carrying a heterozygous mutation in the SGCE gene in comparison to two matched healthy control lines.
[International Journal of Molecular Sciences] |
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| Diamond Blackfan Anemia (DBA) iPSC lines were generated from blood mononuclear cells of DBA patients with inactivating mutations in RPS19 and subjected to hematopoietic differentiation to model disease phenotypes.
[Cells] |
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| Investigators developed two hiPSC/hESC-specific glycan-recognizing mouse antibodies, R-10G and R-17F, using the Tic hiPSC line as an antigen. R-10G recognized a low-sulfate keratan sulfate, and R-17F recognized lacto-N-fucopentaose-1.
[Biomolecules] |
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| The authors evaluated the effect of ionizing radiation on chondrocyte-like cells differentiated from hiPSCs by determining their gene and microRNA expression profile and proteomic analysis.
[Scientific Reports] |
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| Investigators established a hiPSC-derived neuron model for the investigation of axonal lysosome transport and maturation and showed that loss of JIP3 resulted in the accumulation of axonal lysosomes and the Alzheimer’s disease-related amyloid precursor protein-derived Aβ42 peptide.
[Molecular Biology of the Cell] |
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| Scientists discuss current challenges surrounding the generation, delivery, and engraftment of stem cell-derived islet-like cells, along with strategies to induce durable tolerance to grafted cells, with an eye toward a functional cellular-based therapy enabling insulin independence for patients with diabetes.
[Cell Metabolism] |
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| The authors reviewed the molecular basis of reprogramming, including the reprogramming factors, applied vectors and epigenetic modifications to provide a comprehensive guide for reprogramming studies.
[Epigenomics] |
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| Aspect Biosystems announced a new joint development program with JSR Corporation. This collaboration builds on the existing partnership between the two companies and will see the combining of Aspect’s proprietary microfluidic 3D bioprinting platform with JSR’s advanced materials technology to develop implantable vascularized tissues for kidney regeneration and other applications in regenerative medicine.
[Aspect Biosystems, Inc.] |
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| Athersys, Inc. announced that its partner HEALIOS K.K. has completed enrollment in the ONE-BRIDGE study in Japan evaluating MultiStem® in patients with acute respiratory distress syndrome (ARDS) caused by pneumonia.
[Athersys, Inc] |
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| May 17 – 21, 2021
Virtual |
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| | Insitro – South San Francisco, California, United States |
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| | Beam Therapeutics – Cambridge, Massachusetts, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | Gladstone Institute – San Francisco, California, United States |
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| | Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Hepatic Cell News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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