 | | Vol. 16.19 – 19 May, 2021 |
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| Investigators explored the sequence requirements of CCCTC-binding factor (CTCF)-mediated transcriptional insulation using a sensitive insulator reporter in mouse ESCs.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using patient-derived iPSCs, researchers generated a midbrain dopaminergic neuron model of dopamine transporter deficiency syndrome that exhibited marked impairment of dopamine transporter activity, apoptotic neurodegeneration associated with TNFα-mediated inflammation, and dopamine toxicity.
[Science Translational Medicine] |
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| Investigators differentiated human iPSCs into the mesodermal and ectomesodermal lineages to prepare isogenic mesodermal cell–derived chondrocytes and neural crest cell–derived chondrocytes for comparative evaluation.
[Science Advances] |
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| Researchers reported the generation of hypoimmunogenic cancer-antigen-specific T cells derived from induced pluripotent stem cells lacking β2-microglobulin, the class-II major histocompatibility complex (MHC) transactivator and the natural killer cell-ligand poliovirus receptor CD155, and expressing single-chain MHC class-I antigen E.
[Nature Biomedical Engineering] |
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| Researchers showed that 16p11.2 deletion iPSC-derived dopaminergic neurons have increased soma size and synaptic marker expression compared to isogenic control lines.
[Nature Communications] |
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| Scientists reported a protocol differentiating human PSCs into endometrial stromal fibroblasts that were highly pure and able to decidualize.
[Cell Reports] |
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| Using PSCs as a model of human development, researchers revealed that GATA6 was integral to the establishment of the endoderm enhancer network via the induction of chromatin accessibility and histone modifications.
[Cell Reports] |
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| Scientists generated 2D and 3D in vitro human Fragile X syndrome model systems based on isogenic fragile X mental retardation protein (FMRP) knock-out mutant and wild-type human iPSC lines.
[Cell Death & Disease] |
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| Scientists identified a long non-coding RNA, Gm19705, that was over-expressed in hepatocellular carcinoma and mouse ESCs.
[eLife] |
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| Researchers describe the cellular and molecular properties of urine-derived stem cells, their differentiation potency, different reprogramming methods for the generation of iPSCs/induced neural stem cells, and their potential applications in modeling neurological diseases.
[Cell & Bioscience] |
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| Accelerated Biosciences announced new data that further demonstrates statistically significant cytolysis with iPSC-derived natural killer cells programmed from its ethically sourced hTSCs.
[Accelerated Biosciences (BusinessWire, Inc.)] |
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| June 9 – 17, 2021
Virtual |
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| | National Institutes of Health – Rockville, Maryland, United States |
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| | City of Hope – Duarte, California, United States |
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| | German Cancer Research Center – Heidelberg, Germany |
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| | National Institutes of Health – Rockville, Maryland, United States |
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| | NYU Langone Medical Center – New York, New York, United States |
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