 | | Vol. 16.20 – 26 May, 2021 |
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| Scientists identified the epigenetic protein MPP8 as being essential for ground-state pluripotency. Its depletion led to cell cycle arrest and spontaneous differentiation.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Utilizing CRISPR-Cas9, researchers compared the in vitro phenotype of hematopoietic progenitor cells and megakaryocytes derived from iPSC lines harboring mutations in either ETV6 or RUNX1.
[Stem Cell Reports] |
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| Scientists investigated the impact of β-galactocerebrosidase (GALC) deficiency and lentiviral vector-mediated GALC rescue/overexpression in iPSC-derived neural progenitors and neuronal/glial progeny obtained from two globoid cell leukodystrophy patients.
[Stem Cell Reports] |
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| Researchers discovered crosstalk between AMPA/Kainate-type ionotropic glutamate receptors and the Wnt-pathway during the initial Wnt3a-interaction at the cytonemes of mouse ESCs. They demonstrated that this crosstalk persisted throughout the Wnt3a-response in ESCs.
[eLife] |
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| The global transcriptome data of various tissues and cell lines and quantitative expression analysis of PSCs showed that ESRG expression was much higher than other human endogenous retrovirus type-Hs and tightly silenced after differentiation.
[PLOS Genetics] |
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| Researchers generated iPSCs from three different GS-2 patients using lentiviral vectors. The iPSCs were characterized using flow cytometry and RT-PCR and tested for the expression of pluripotency markers. In vivo differentiation to cells from all three germlines was tested using a teratoma assay.
[Stem Cell Research & Therapy] |
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| CRISPR/Cas9-mediated individual or compound deletion of the two enhancers significantly inhibited HoxB gene expression, and transcriptome analysis revealed that retinoic acid-induced early ESCs differentiation was blocked in the enhancer KO cells.
[Stem Cells and Development] |
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| Simplified conditions will facilitate the use of bovine ESCs for gene editing applications and pluripotency and lineage commitment studies.
[Scientific Reports] |
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| Scientists presented the generation and characterization of a cohort of seven homozygous familial hypercholesterolemia-iPSC lines derived from peripheral blood mononuclear cells collected from four homozygous and three compound heterozygous patients.
[Stem Cells and Development] |
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| The authors summarize recent findings from studies using hiPSC-based modelling of spinocerebellar ataxias, and discuss what knowledge has been gained from these studies.
[Stem Cell Reviews and Reports] |
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| The International Society for Stem Cell Research relaxed the famous 14-day rule on culturing human embryos in its latest research guidelines.
[Nature News] |
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| July 12 – 15, 2021
Virtual |
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| | Columbia University Medical Center – New York, New York, United States |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | City of Hope – Duarte, California, United States |
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| | NYU Langone Medical Center – New York, New York, United States |
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| | National Institutes of Health – Rockville, Maryland, United States |
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