 | | Vol. 16.21 – 2 June, 2021 |
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| Scientists established a differentiation strategy that promoted the specification, proliferation and maturation of compact ventricular cardiomyocytes from human PSCs.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In situ hybridization, immunolabelling, cell tracking and transcriptomic analyses showed that the embryoids form the three germ layers through a gastrulation process and that they exhibited a wide range of developmental structures, highly similar to neurula-stage mouse embryos.
[Nature Communications] |
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| Investigators probed the effect of the Zbtb46 transcription factor in ESC-derived blood cell progenitors using chemically inducible mouse cell lines.
[Stem Cells] |
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| Researchers used a commercial maturation medium intended to promote the maturation status of human iPSC-cardiomyocytes, and compared the parameters with the ones obtained with standard culture medium, and with freshly dissociated mouse cardiomyocytes.
[Bioinformatics] |
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| Investigators generated a ubiquitin-specific protease 3 gene knockout using the CRISPR/Cas9 system and demonstrated that USP3 acted as a protein stabilizer of Oct4 by deubiquitinating Oct4.
[International Journal of Molecular Sciences] |
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| Researchers generated three human-iPSC lines from peripheral blood mononuclear cells of two long QT syndrome type 2 (LQT2) patients carrying pathogenic variants and one LQT2 patient carrying a variant of uncertain significance in KCNH2.
[Stem Cell Research] |
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| The authors investigated whether a generation of an adenovirus vectors that possess a suicide gene allow for detection of undifferentiated human iPSCs in preparations of human iPSC-derived neural progenitor cells, which have been expected to treat neurological disorders.
[Scientific Reports] |
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| Researchers conducted sequential LC/MS/MS analyses of tryptic digest, enriched glycopeptides, and deglycosylated peptides of proteins derived from human iPSCs and iPSC-derived neuronal cells, which were used as a model of neuronal differentiation.
[Scientific Reports] |
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| To study the molecular mechanisms of Usher syndrome and develop a gene therapy strategy, investigators generated human iPSCs from peripheral blood mononuclear cells obtained from a patient carrying compound heterozygous variants of USH2A c.2299delG and c.1256G>T and the patient’s healthy sibling.
[Genes] |
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| Scientists found that the HO-1 gene was expressed in ESCs and induced after promoting differentiation. Downregulation of the pluripotency transcription factor (TF) OCT4 increased HO-1 mRNA levels in ESCs, and analysis of ChIP-seq public data revealed that this TF bound to the HO-1 gene locus in pluripotent cells.
[FEB Letters] |
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| A culture system with bubble sparging for human iPSC proliferation was designed using a plastic fluid as a culture medium.
[Journal of Bioscience and Bioengineering] |
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| The authors provide a brief overview of iPSCs and discusses recent advances in the establishment of induced nduced tissue-specific stem cells and their possible applications in regenerative medicine.
[Pharmaceutics] |
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| By analyzing each stage of the drug discovery and development process, scientists identified the active role of human PSC-derived in vitro models in phenotypic screening, target-based screening, target validation, toxicology evaluation, precision medicine, clinical trial in a dish, and post-clinical studies.
[Pharmaceuticals] |
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| Dr. Partha Das of Monash University’s Biomedicine Discovery Institute has been announced as the recipient of the Prader Willi Research Foundation Australia 2020 Prader-Willi Syndrome (PWS) Grant Round. Dr. Das’ project will grow and study 3D brain organoids from people with PWS.
[Monash University] |
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| June 16 – 17, 2021
Virtual |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | City of Hope – Duarte, California, United States |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | NYU Langone Medical Center – New York, New York, United States |
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