 | | Vol. 16.22 – 9 June, 2021 |
| |
|
|
| To efficiently cluster human PSC-derived pancreatic progenitors into 3D structures, scientists discovered ten chemicals that not only retained the pancreatic progenitors in 3D clusters but also enhanced their potentiality towards NKX6.1+/INS+β cells.
[Nature Communications] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Using a highly parallelized approach to investigate pioneer transcription factor ability to bind methylated DNA and induce DNA demethylation, researchers showed the complex interdependence between DNA methylation and transcription factor binding.
[Nature Communications] |
|
|
|
| Efficient reprogramming of human fibroblasts to iPSCs was achieved by transduction with vectors expressing SOX2, KLF4, and inducible dnAP-1, demonstrating that dnAP-1 can substitute for exogenous human OCT4.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| The authors performed an integrated analysis of DNA methylation, chromatin accessibility, and gene expression across hundreds of human PSC samples.
[Cell Reports] |
|
|
|
| Scientists reported that a common mechanism for the initiation of the erosion of X chromosome inactivation of female human PSCs depended on XIST loss but not XACT accumulation on inactive X chromosomes.
[Cell Reports] |
|
|
|
| Investigators showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet was positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.
[iScience] |
|
|
|
| Researchers established tumor-specific tumor-infiltrating lymphocytes (TIL)-derived iPS cells with human colorectal cancer specimens to confirm their hypothesis that the anti-tumor effect could be enhanced by TIL regeneration.
[Communications Biology] |
|
|
|
| Bioengineered skeletal muscles produced functional tetanic and twitch profiles and demonstrated increased acetylcholine receptor clustering and transcription of MUSK and LRP4 mRNAs, indicating enhanced organisation of the post-synaptic membrane.
[Scientific Reports] |
|
|
|
| The authors assessed similarities and differences between commercially available iPSC hepatocytes and primary human hepatocytes in preliminary assays of drug metabolism, hepatotoxicity, and drug transport.
[Journal of Pharmacological and Toxicological Methods] |
|
|
|
| Researchers differentiated human ESCs to early cardiac mesodermal cells in microfluidic chambers that had a volume of only 30 nanoliters, using discontinuous medium perfusion. To confirm cell pluripotency, they tracked human ESC proliferation and immunostained the cells for pluripotency markers SOX2 and OCT3/4.
[Biomedical Microdevices] |
|
|
|
|
| The authors discuss strategies that ameliorate tumor mechanics, such as those that foster the mesenchymal-like transdifferentiation of cells to induce a stem-like phenotype, which may comprise an effective strategy to prevent aggressive tumor behavior.
[Developmental Cell] |
|
|
|
| Scientists provide an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human iPSCs derived from healthy and diseased subjects.
[Stem Cell Reviews and Reports] |
|
|
|
|
| BlueRock Therapeutics announced the dose administration for the first patient in a Phase I, open-label study of PSC-derived dopaminergic neurons in patients with advanced Parkinson’s disease.
[BlueRock Therapeutics] |
|
|
|
| Sorrento Therapeutics, Inc. announced that the Company has entered into an additional collaborative agreement with NextGenNK Competence Center-associated research groups at the Karolinska Institutet in Stockholm, Sweden, aimed at producing novel cell-based therapeutics using natural killer cells derived from induced pluripotent stem cells.
[Sorrento Therapeutics, Inc.] |
|
|
|
|
| June 21 – 24, 2021
Virtual |
|
|
|
|
|
| | Western University of Health Sciences – Lebanon, Oregon, United States |
|
|
|
| | Columbia University Medical Center – New York, New York, United States |
|
|
|
| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
|
|
|
| | University of British Columbia – Vancouver, British Columbia, Canada |
|
|
|
| | NYU Langone Medical Center – New York, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
