 | | Vol. 16.24 – 23 June, 2021 |
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| Investigators reported a novel type of nucleic acid-based antiviral system that existed in mouse ESCs (mESCs), which suppressed RNA virus infection by DNA-mediated RNA cleavage, providing intriguing insights into the antiviral mechanism of mESCs.
[Cell Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers characterized key events of human embryo morphogenesis, in the period between implantation and gastrulation, using single-cell analysis and functional studies.
[Nature Communications] |
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| The authors investigated the role of methylation of the core methyltransferase METTL3/METTL14 in m6A regulation. They found that global mRNA m6A levels were greatly decreased in METTL14 R255K mutant mouse ESCs (mESCs) and that that loss of R255me preferentially affected endoderm differentiation in mESCs.
[Nature Communications] |
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| Scientists examined the impact of Ino80 deletion in naïve and primed PSCs. They found that Ino80 deletion had minimal effect on self-renewal and gene expression in the naïve state, but led to cellular differentiation and de-repression of developmental genes in the transition toward and maintenance of the primed state.
[Nucleic Acids Research] |
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| Researchers generated transgenic mice with knocked-in mosaic analysis with double markers (MADM) cassettes near the centromeres of all 19 autosomes and validated their use across organs. They applied their MADM library to systematically trace sister chromatid segregation in distinct mitotic ESC lineages.
[Cell Reports] |
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| Investigators showed that truncation of the DIDO gene altered RNA splicing and transcription termination in ESC and mouse embryo fibroblasts, which affected genes involved in both differentiation and reprogramming.
[Cell Death & Disease] |
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| The authors developed a rapid protein-level OCT4 depletion system that demonstrated that the immediate downstream response to loss of OCT4 was reduced expression of key pluripotency factors.
[Stem Cell Reports] |
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| RNA-seq, quantitative RT-PCR and western blot analysis were applied to study the role of RNF20 and H2B ubiquitination during mouse somatic cell reprogramming.
[Cell Proliferation] |
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| Stress-induced changes in viral receptor and susceptibility gene expression were measured in ESCs and differentiated progeny. Bulk RNAseq transcriptomic analysis showed significant upregulation of two genes involved in COVID-19 cell uptake, Vimentin and Transmembrane Serine Protease 2.
[Stem Cell Reviews and Reports] |
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| Researchers reported SpCas9 nuclease variant (SpCas9-NG)-mediated repair of the abnormally expanded CAG repeat tract in Huntington’s disease (HD). By targeting the boundary of CAG repeats with SpCas9-NG, they contracted the repeat tracts in HD-mouse-derived ESCs.
[Communications Biology] |
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| The authors employed a robust method, without the need for mouse co-culture to generate 3D cerebellar organoids from human PSCs that displayed hallmarks of in vivo cerebellar development.
[Scientific Reports] |
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| Investigators discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organizing cultures, or by controlled assembly through microfluidic and print-based technologies.
[Communications Biology] |
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| Scientists provide highlights on the development of organoid technology, and the use of this culture system to study the pathophysiology of specific mutations in the development of pancreatic and gastric cancer.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| The annual Vagelos Precision Medicine Pilot Grants have been awarded to five teams of VP&S researchers conducting innovative basic science, translational, and clinical research across multiple diseases, from novel cancer therapeutics to health disparities research.
[Columbia University Irving Medical Center] |
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| The Canadian federal government announced more than 150 new and renewed Canada Research Chairs (CRCs) at institutions across the country. Dr. Jack Chu’s successful CRC Tier II application focused on using stem cells to model human and animal developmental clocks and related disorders.
[University of Calgary] |
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| August 12 – 14, 2021
Busan, South Korea |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Stanford University – Stanford, California, United States |
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| | Sana Biotechnology – Seattle, Washington, United States |
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| | University of Bristol- Bristol, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
