 | | Vol. 16.27 – 14 July, 2021 |
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| Researchers identified an isoform of Dicer, named antiviral Dicer, that protected tissue stem cells from RNA viruses—including Zika virus and severe acute respiratory syndrome coronavirus 2—by dicing viral double-stranded RNA to orchestrate antiviral RNA interference.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators combined human iPSCs and airway-on-a-chip technology to demonstrate the effectiveness of fluid shear stress for regulating the global axis of multicellular planar cell polarity, as well as inducing ciliogenesis, thereby contributing to quantifiable unidirectional mucociliary flow.
[Science Translational Medicine] |
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| A low-cost protocol for cardiomyocyte differentiation from mouse ESCs was presented and it was shown that Pten deletion potently suppressed cardiomyocyte differentiation.
[Advanced Science] |
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| Scientists established directed differentiation models to generate tendon and fibrocartilage cells from mouse ESCs by activation of TGFβ and hedgehog pathways, achieving 90% induction efficiency.
[Nature Communications] |
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| The authors showed that conditional Satb2 gene inactivation weakened ESC pluripotency, and identified SUMO2 modification of SATB2 by the E3 ligase ZFP451 as a potential driver of ESC differentiation.
[Genes & Development] |
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| Researchers described an optimized protocol to differentiate human iPSCs to a late myogenic stage, allowing them to recapitulate classical Duchenne muscular dystrophy (DMD) phenotypes in isogenic DMD-mutant iPSC lines in vitro.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators identified O-GlcNAcylation of proteasome activator subunit 3 (Psme3) protein as a node of the ESC pluripotency network. Mechanistically, O-linked β-N-acetylglucosamine modification of serine 111 of Psme3 promoted degradation of Ddx6, which was essential for processing body assembly, resulting in the maintenance of ESC pluripotent state.
[Cell Reports] |
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| Scientists investigated the contribution of the X-linked intellectual disability (XLID)-associated RBMX in neuronal differentiation.Transcriptomic analysis of isogenic Shashi-XLID human iPSCs generated using CRISPR-Cas9 revealed a dysregulation of MDM4 splicing and aberrant p53 upregulation.
[Cell Reports] |
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| Researchers used Costello syndrome iPSCs undergoing osteogenic differentiation to investigate how dysregulation of extracellular matrix (ECM) remodeling proteins contributed to impaired osteogenesis.
[Stem Cell Reports] |
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| Investigators proposed a novel strategy to generate hindbrain serotonin (5-HT) neurons from human PSCs, which involved the formation of ventral-type neural progenitor cells and stimulation of the hindbrain 5-HT neural development.
[Stem Cell Reports] |
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| Scientists generated a 3D placental organ bud from human iPSCs. The iPSCs differentiated into various lineages of trophoblasts such as cytotrophoblast-like, syncytiotrophoblast-like, and extravillous trophoblast-like cells, forming organized layers in the bud.
[Scientific Reports] |
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| Inborn errors of metabolism constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. The authors discuss six lessons that they have learned from those previous modeling efforts.
[Reviews in Endocrine & Metabolic Disorders] |
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| Transcription factor-induced reprogramming of somatic cells across lineages and to iPSCs has revealed a remarkable plasticity of differentiated cells and presents great opportunities for generating clinically relevant cell types for disease modeling and regenerative medicine.
[Current Opinion in Genetics & Development] |
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| ExCellThera, Inc. announced that it has entered into a licensing agreement with Astellas Pharma, Inc. through its US subsidiary, Astellas Institute for Regenerative Medicine, for the in vitro use of the UM171 compound and certain other molecules in the field of PSCs and PSC-derived cells.
[ExCellThera, Inc.] |
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| September 5 – 8, 2021
Exeter, England, United Kingdom |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | Stanford University – Palo Alto, California, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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