 | | Vol. 16.35 – 8 September, 2021 |
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| Using a combination of a human PSC–derived cancer model along with zebrafish transgenesis, researchers demonstrated that the transforming ability of BRAFV600E along with additional mutations depended on the intrinsic transcriptional program present in the cell of origin.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed an in vitro reconstitution of whole male germ-cell development by PSCs. Mouse ESCs were induced into primordial germ cell-like cells, which were expanded for epigenetic reprogramming.
[Cell Stem Cell] |
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| The authors used CRISPR-Cas9 genome editing of iPSCs to create a synthetic gene circuit that sensed changing levels of endogenous inflammatory cytokines to trigger a proportional therapeutic response.
[Science Advances] |
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| Scientists performed extensive single-cell transcriptomic analyses to map fate choices and gene expression patterns during hematopoietic differentiation of human PSCs and showed that oxidative metabolism was dysregulated during in vitro directed differentiation.
[Science Advances] |
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| Researchers mapped the OCT4 interactomes in naïve and primed human ESCs (hESCs), revealing extensive connections to mammalian ATP-dependent nucleosome remodeling complexes. In naïve hESCs, OCT4 was associated with both BRG1 and BRM, the two paralog ATPases of the BAF complex.
[Nature Communications] |
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| Investigators generated a induced pluripotent stem cell Alzheimer’s disease model using human derived cells, which showed signs of Aβ plaques, dystrophic neurites around plaques, synapse loss, dendrite retraction, axon fragmentation, phospho-Tau induction, and neuronal cell death in one model.
[Nature Communications] |
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| Scientists established a stepwise method to differentiate iPSCs into retinal pigment epithelium (RPE) (iPSC-RPE), which enabled efficient isolation and purification of patient-derived iPSC-RPE cells with high quality.
[Methods in Molecular Biology] |
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| Researchers presented a human in vitro model permitting investigation of epithelial-intrinsic events culminating in AEC2 dysfunction, using patient-specific iPSCs carrying an AEC2-exclusive disease-associated variant (SFTPCI73T).
[Cell Reports] |
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| The authors developed a 3D, two-step induction protocol for generating blastocyst-like structures from human extended PSCs.
[Cell Discovery] |
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| Scientists showed that the aryl hydrocarbon receptor (AhR) regulated pluripotency factors and maintained the metabolic activity required for proper embryo differentiation. AhR-lacking embryos showed a pluripotent phenotype characterized by a delayed expression of trophectoderm differentiation markers.
[Stem Cell Reports] |
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| Using human ESCs as well as human iPSCs, investigators demonstrated that the level of reactive oxygen species in pluripotent cells oscillated in accordance with the cell cycle progression with the peak occurring at transition from S to G2/M phase of the cycle.
[Stem Cells] |
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| The chromatin accessibility and transcriptional level of human ESCs and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing and RNA sequencing RNA-seq to identify potential reprogramming factors.
[Stem Cell Reviews and Reports] |
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| Researchers presented the generation and application of a fluorescent human iPSC reporter line for heme oxygenase-1, which was considered a sensitive and reliable biomarker for the oxidative stress response.
[Archives of Toxicology] |
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| The authors discuss the potential regenerative capacity of the remaining islet cells and the utility of stem cell-derived β-like cells to restore β-cell function and describe tissue engineering approaches that might improve the engraftment, function, and survival of β-cell replacement therapies.
[Lancet Diabetes & Endocrinology] |
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| Investigators review the use of human PSCs for skeletal tissue engineering, the different methods for characterization of skeletal cells and constructs at the tissue and single-cell level, and indicate newer resources not yet fully utilized in this field.
[Critical Reviews in Biotechnology] |
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| Adaptimmune Therapeutics plc announced that it has entered into a strategic collaboration and license agreement with Genentech to develop and commercialize allogeneic cell therapies to treat multiple oncology indications. Adaptimmune will be responsible for developing clinical candidates using its iPSC derived allogeneic platform to produce T-cells.
[Adaptimmune Therapeutics plc] |
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| October 19 – 20, 2021
Virtual |
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| | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Helmholtz Zentrum Münche – Neuherberg, Germany |
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| | Stanford University – La Jolla, California, United States |
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| | Danaher – Toronto, Ontario, Canada |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
