 | | Vol. 16.36 – 15 September, 2021 |
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| Natural killer (NK) cells derived from uniformly engineered iPSCs, termed iADAPT, displayed metabolic features and gene expression profiles mirroring those of cytomegalovirus-induced adaptive NK cells.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed hydrogels that enabled mouse ESCs (mESCs) to maintain stemness in vitro in the absence of both leukemia inhibitory factor and mouse embryonic fibroblasts, two critical factors in the standard protocol for mESC maintenance.
[ACS Nano] |
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| Comprehensively analyzing the mitochondrial genome in 146 iPSC and fibroblast lines from 151 donors, researchers showed that most age-related fibroblast mtDNA mutations were lost during reprogramming.
[Nature Communications] |
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| Scientists observed that ESCs deficient for both Dnmt3a and Dnmt3b were rapidly eliminated from chimeras, and found that in vivo and in vitro the formative pluripotency transition was derailed toward production of trophoblast.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors found that genetic deletion of the four genes encoding the TCF/LEF transcription factors confered mouse ESCs (mESCs) with the ability to self-renew in N2B27 medium alone, identifying TCF/LEF effectors that mediated exit from the pluripotent state.
[Cell Reports] |
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| By employing their recently developed retina on chip that merged organoid and organ-on-chip technology, investigators analyzed the efficacy, kinetics, and cell tropism of seven first- and second-generation adeno-associated virus (AAV) vectors.
[Stem Cell Reports] |
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| Researchers applied single-nuclei and single-cell transcriptomics to model interneuron development from human cortex and interneurons derived from PSCs, and provided a direct comparison of various in vitro interneuron derivation methods to determine the homogeneity achieved.
[Stem Cell Reports] |
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| Scientists reported that the conjunct activity of two orphan nuclear receptors, Esrrb and Nr5a2, paralleled the importance of that of Oct4 and Sox2 in naïve mouse ESCs. By occupying a large common set of regulatory elements, these two factors controlled the binding of Oct4, Sox2 and Nanog to DNA.
[Development] |
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| Investigators established a simple method to convert human pluripotent stem cells into skeletal muscle cells by using temperature-sensitive Sendai virus vector encoding myoblast determination protein, a myogenic master transcription factor.
[Journal of Cellular and Molecular Medicine] |
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| The authors described a two-step chemically defined xeno-free method for generating valvular endothelial cell (VEC)-like cells (VELs) from human PSCs (hPSC). When seeded onto the surface of the de-cellularized porcine aortic valve matrix scaffolds, hPSC-derived VELs exhibited superior proliferative and clonogenic potential than the primary VECs and human aortic endothelial cells.
[Communications Biology] |
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| Using both human induced pluripotent stem cells and mouse models, researchers found that FUS-ALS causative mutations affected the activity of two relevant RNA-binding protein with important roles in neuronal RNA metabolism: HuD/ELAVL4 and FMRP.
[Communications Biology] |
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| By combining next generation whole exome sequencing and iPSC technology, scientists found that an Alu repeat inserted in exon 9 of the MAK gene resulted in a loss of normal MAK transcript and development of human autosomal recessive retinitis pigmentosa.
[Gene Therapy] |
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| Researchers optimized an homology-directed repair (HDR)-mediated knock-in method for mouse ESCs by improving the efficiency of HDR-mediated knock-in of a plasmid donor while almost completely suppressing non-homologous end joining/microhomology-mediated end joining-based integration.
[Scientific Reports] |
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| Genetic variants play an important role in conferring risk for cardiovascular diseases (CVDs). The authors summarize recent progress and new strategies in deciphering pathogenic variants for CVDs using CRISPR-edited human iPSCs.
[Trends in Genetics] |
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| Scientists discuss major factors to consider for the development of cardiovascular tissues from stem cell derived cardiomyocytes, examine important considerations in undertaking a cardiovascular tissue engineering project, and present, interpret, and summarize some of the recent advancements in this field.
[Tissue Engineering Part B-Reviews] |
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| Separating the rejuvenative properties of reprogramming from dedifferentiation is a promising prospect, termed epigenetic rejuvenation. Investigators review the development and potential of reprogramming-induced rejuvenation as an anti-aging strategy.
[Clinical Epigenetics] |
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| Gain Therapeutics, Inc. announced topline data from the company’s study, conducted at the University of Maryland School of Medicine. The study, evaluating two lead Structurally Targeted Allosteric Regulators (STARs) compounds for the treatment of Gaucher and GBA1 Parkinson’s Disease, demonstrated positive effects on all tested phenotypes.
[Gain Therapeutics, Inc.] |
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| ONK Therapeutics Ltd announced that the US Patent and Trademark Office has granted its licensed patent that covers CISH knockout in natural killer (NK) cells, irrespective of the source of the NK cells, including, for example, human cord blood-derived and human iPSC-derived cells
[ONK Therapeutics Ltd] |
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| November 15 – 17, 2021
Virtual |
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| | Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Helmholtz Zentrum Münche – Neuherberg, Germany |
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