 | | Vol. 16.41 – 20 October, 2021 |
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| Directed differentiation of human PSCs revealed that loss of One Cut Homeobox 1 (ONECUT1) impaired pancreatic progenitor formation and a subsequent endocrine program.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellular development of human embryonic stem cells and neuroprogenitor cells.
[Nature Communications] |
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| Given the proliferation and adhesion defect of Trpm7−/− trophoblast stem cells and the ability of Trpm7−/− ESCs to develop to embryos in tetraploid embryo complementation assays, researchers postulated a critical role of TRPM7 in trophectoderm cells.
[Cell Reports] |
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| Investigators examined the roles of neuropilin-1, basigin, transmembrane serine proteases (TMPRSSs), and cathepsins in SARS-CoV-2 infection using the CRISPR interference system and angiotensin-converting enzyme2-expressing human iPSCs.
[Molecular Therapy-Nucleic Acids] |
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| TBX3 mutant human PSC lines were generated using CRISPR/Cas9 genome editing. TBX3 loss led to impaired liver differentiation and an upregulation of pancreatic gene expression, including PDX1, during a hepatocyte differentiation protocol.
[Stem Cell Reports] |
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| Researchers modeled Fabry disease using human iPSC-derived kidney organoids and the CRISPR–Cas9 genome-editing system.
[Experimental & Molecular Medicine] |
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| The authors generated NMPs from human ESCs, subsequently derived MSCs and characterized this cell population in vitro and in vivo. NMP-derived MSCs were plastic adherent fibroblast like cells with colony forming capacity and trilineage differentiation potential.
[Stem Cell Reviews and Reports] |
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| Utilizing iPSCs from 25 human donors, scientists generated 3D cerebral organoids, employed 16-plex isobaric sample-barcoding chemistry, and simultaneously subjected samples to comprehensive high-throughput liquid-chromatography/mass-spectrometry quantitative proteomics.
[Translational Psychiatry] |
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| Researchers checked transcriptional profiles by microarray and found the Hippo pathway was changed and the activity of YAP decreased during mesoderm-mediated endothelial cell differentiation from human ESCs.
[Journal of Molecular and Cellular Cardiology] |
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| Investigators described methods for ex vivo generation of megakaryocytes and functional platelets from human iPSCs in a scalable fashion.
[Scientific Reports] |
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| To apply the iPSC-based cell therapy in an allogeneic setting, the authors developed a method in which non-T cell-derived iPSCs were transduced with exogenous T cell receptor genes.
[International Immunology] |
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| Researchers demonstrated the generation of Mucopolysaccharidosis type IIIA (MPS IIIA) iPSCs and neural progenitor cells, the latter of which display reduced proliferation and neurogenic capacity.
[Molecular Genetics and Metabolism Reports] |
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| The authors analyze sex-related properties of the heart muscle in the context of health and disease and discuss a framework for including sex-based differences in human cardiac tissue engineering.
[Nature Reviews Materials] |
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| Recent studies of cultured mouse and human PSCs have identified cells representative of an intermediate stage between naive pluripotency and primed pluripotency. Scientists examine these recent findings in light of our knowledge of peri-implantation mouse and human development.
[Cell Stem Cell] |
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| Investigators discuss strategies for scaling stem cell differentiation through multiplexed single-cell analysis, for evaluating molecular regulation of cell differentiation using new analysis algorithms, and methods for integration and projection analysis to classify and benchmark stem cell derivatives against in vivo cell types.
[Trends in Molecular Medicine] |
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| The SynGAP Research Fund (SRF) announces grants to Drs. April Levin, Mustafa Sahin and Annapurna Poduri of Boston Children’s Hospital to advance SYNGAP1 biomarker characterization and genotype-phenotype analysis.
[SynGAP Research Fund] |
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| November 8 – 16, 2021
Chicago, Ilinois, United States & Online |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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| | The International Society for Cell & Gene Therapy – Vancouver, British Columbia, Canada |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | King Abdullah University of Science and Technology – Thuwal, Saudi Arabia |
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