 | | Vol. 16.49 – 15 December, 2021 |
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| Researchers showed that histone variant H3.3 actively marked enhancers and cooperated with H2A.Z at promoters to prime the genes into a poised state in mouse embryonic stem cells.
[Nucleic Acids Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists described a mouse embryonic stem cell-based system to quantitatively determine the functional impact of 50 missense variants of uncertain significance in human checkpoint kinase 2 (CHEK2) .
[Cancer Research] |
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| The authors bioengineered a physiologically relevant 3D scaffold by integrating brain-like extracellular matrix components and chemical cues.
[Acta Biomaterialia] |
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| Researchers determined whether GSK-3484862 could induce demethylation more effectively than 5-azanucleosides. They determined the cytotoxicity and optimal concentration of GSK-3484862 by treating wild-type or Dnmt1/3a/3b triple knockout murine ESCs with different concentrations of the compound, which was obtained from two commercial sources.
[Epigenetics & Chromatin] |
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| In iPSC-derived retinal pigment epithelium from late-onset retinal degeneration patients, investigators showed that the dominant pathogenic CTRP5 variant led to reduced CTRP5 secretion.
[Communications Biology] |
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| Scientists explored the toxic effects and mechanisms of trichloroethylene (TCE) on human ESC (hESC) proliferation. TCE exposure resulted in upregulation of Cx43 via Akt phosphorylation, consequently stimulated CDK2 expression, contributing to hyper-proliferation in hESCs.
[Toxicology] |
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| Based on a chemical screening, the authors developed a new recipe for efficient induction of progenitors of motor neurons (pMN) progenitors from human embryonic stem cells.
[Journal of Molecular Cell Biology] |
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| Before co-culture, stem cells from human exfoliated deciduous teeth’s (SHED) mitochondria and ESCs’s cell membranes were separately labeled with specific fluorescent probes. After co-culture, SHED’s mitochondria were tracked by fluorescent microscope and flow cytometry analysis.
[Neuroscience Letters] |
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| Scientists showed accurate tracking of the aging process in hepatocytes, demonstrated attenuated epigenetic aging in muscle stem cells and tracked age dynamics in ESCs.
[Nature Aging] |
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| The authors review some of the emerging strategies in use to engineer chimeric antigen receptor (CAR)-expressing iPSC-derived drug products.
[Archivum Immunologiae et therapiae Experimentalis] |
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| BlueCube Bio officially announced a company name transition to Evia Bio™, concurrent with the launch of a significant new cryopreservation technology for use in cell and gene therapies utilizing iPSCs.
[BlueCube Bio (BioSpace, Inc.)] |
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| March 9 – 11, 2022
Melbourne, Victoria, Australia |
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| University of Luxembourg – Luxembourg, Luxembourg |
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| | Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States |
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| | KU Leuven – Leuven, Belgium |
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| | King’s College London – London, England, United Kingdom |
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| | NIH National Institute of Environmental Health Sciences – Research Triangle Park, NC, United States |
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