 | | Vol. 17.03 – 26 January, 2022 |
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| Scientists identified thousands of dual regions in mouse ESCs that relied on the histone methyltransferases SET domain bifurcated 1 (SETDB1) and nuclear set domain (NSD)-containing proteins to generate H3K9me3 and H3K36me3, respectively.
[Molecular Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed an adenine base editor-based strategy to systematically identify functional m6A sites that controlled lineage decisions of human ESCs.
[Nature Communications] |
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| Researchers engineered guide RNAs (gRNAs) with highly stable hairpins in their constant parts and further enhanced their stability by chemical modifications.
[Nature Communications] |
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| Skeletal muscle myoblasts (iMyoblasts) were generated from human iPSCs using an efficient and reliable transgene-free induction and stem cell selection protocol.
[eLife] |
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| Scientists showed that PIKfyve inhibitors could selectively eliminate pluripotent embryonal carcinoma cells, ESCs, and iPSCs under conditions where differentiated cells remained viable.
[Stem Cell Reports] |
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| Investigators described a high-efficiency reprogramming of human somatic cells into iPSCs using optimized CRISPR activation.
[Stem Cell Reports] |
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| Researchers evaluated the splicing isoforms of histone variant macroH2A1, macroH2A1.1 and macroH2A1.2, as potential regulators of DNA damage repair during iPSC reprogramming.
[Stem Cells] |
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| The authors suggested that Djplac8-A acted as a molecular switch of piwi+ stem cells for entry into the regenerative state after amputation.
[Development] |
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| Investigators demonstrated that the replacement of meiotic spindles in mature metaphases II arrested oocytes with nuclei of somatic cells in the G0/G1 stage of cell cycle resulted in the formation of de novo spindles consisting of somatic homologous chromosomes comprising of single chromatids.
[Communications Biology] |
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| Scientists developed a mass spectrometry-based proof-of-concept to assess a histone code screening assay capable of simultaneously detecting multiple histone post-translational modifications-changes in human ESCs.
[Scientific Reports] |
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| Researchers found that enrichment of common organic matrices by black phosphorus could improve discrimination data analysis by enhancing peak intensity and reproducibility of mass spectra acquired from intact cells.
[Scientific Reports] |
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| The authors discuss new insights into human embryogenesis gathered from successes in culturing human embryos in vitro and stem-cell-based embryo models.
[Developmental Cell] |
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| Scientists introduce the research advance of both somatic cell reprogramming and early embryonic development, indicating that the mechanisms of iPSCs also shares common features with that of early embryonic development in several aspects.
[Molecular Reproduction and Development] |
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| Pluristyx, Inc., panCELLa, and Implant Therapeutics announced they have entered into a manufacturing and distribution strategic alliance that offers cell therapy companies streamlined access to the next generation of safe, universal, cost-effective, “off-the-shelf” iPSCs.
[Pluristyx, Inc.] |
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| April 3 – 6, 2022
Warwick, England, United Kingdom |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Mayo Clinic Florida Campus – Jacksonville, Florida, United States |
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| | UK Research and Innovation – Oxfordshire, England, United Kingdom |
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