 | | Vol. 17.04 – 2 February, 2022 |
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| Scientists showed that the BRG1/BRM-associated factor chromatin-remodeling complex ATPase gene Brm safeguarded cell identity during directed cardiogenesis of mouse ESCs.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers characterized the expression pattern and examined the function of Lima1 in mouse embryos and PSC lines.
[Nature Communications] |
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| By elucidating the in vivo molecular features of the renal stromal lineage at a single-cell resolution level, investigators established an in vitro induction protocol for stromal progenitors from mouse PSCs.
[Nature Communications] |
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| By developing a measure that tracked cellular aging in vitro, scientists tested whether it tracked physiological aging in various mouse tissues and whether anti-aging interventions modulate this measure.
[Aging Cell] |
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| Investigators interrogated the contribution of the Hippo signaling effector YAP1 to the formation of the three germ layers by analyzing human ESC-derived 2D-micropatterned gastruloids.
[Stem Cell Reports] |
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| The authors used Duchenne muscular dystrophy-patient-specific human iPSCs to model cardiomyopathic features and unravel novel pathologic insights.
[Stem Cell Reports] |
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| The presence of artificial introns, particularly an intron that carried an enhancer element, significantly increased the reporter expression levels in iPSCs compared to the intron-deleted control.
[Stem Cell Reviews and Reports] |
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| Scientists inserted iCasp9 gene into the endogenous OCT4 locus of human and mouse PSCs without affecting their pluripotency. A chemical inducer of dimerization, AP1903, induced iCasp9 activation, which led to the apoptosis of specific undifferentiated PSCs in vitro and in vivo.
[Molecular Therapy-Methods & Clinical Development] |
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| Researchers optimized and functionally linked magnetic activated cell sorting technology as well as multiplex droplet digital PCR to their ESC screening process to achieve a greater than 60% assurance that ESC clones were correctly targeted.
[Molecular Biology Reports] |
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| The authors summarize currently used differentiation strategies of iPSCs towards neuronal and glial cell types and cerebral organoids and their utilization in modeling Alzheimer’s disease and potential drug discovery.
[Stem Cell Reviews and Reports] |
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| The ISS will include an experiment by five students from the Luxembourg Center of System Biomedicine at Belval, who have been growing so-called “organoids”, mini brains that will be able to grow in micro gravity and thus help advance research in the fight against Parkinson’s disease.
[RTL Luxembourg] |
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| 27 Apr 2022 – 01 May 2022
Riviera Maya, Mexico |
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| | Stanford University – Stanford, California, United States |
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| | University of Nottingham – Nottingham, England, United Kingdom |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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