 | | Vol. 4.30 – 9 February, 2022 |
| |
|
|
| Scientists generated islets from human chemically induced PSCs (hCiPSC-islets) and showed that a one-dose intraportal infusion of hCiPSC-islets into diabetic non-human primates effectively restored endogenous insulin secretion and improved glycemic control.
[Nature Medicine] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The researchers’ approach of remodeling the pericentromeric heterochromatin and re-establishing the totipotency-specific broad H3K4me3 domains promoted the pluri-to-totipotency transition.
[Cell Stem Cell] |
|
|
|
| The authors indicated that canonical Wnt signaling was required in a precise and regulated manner for normal choroid plexus development in the mammalian brain.
[Nature Communications] |
|
|
|
| To dissect the dynamic regulation of Runx1 in hematopoietic development, researchers analyzed its 3D chromatin conformation in mouse ESC differentiation cultures.
[Nature Communications] |
|
|
|
| Investigators described how to grow human PSCs such as human induced pluripotent and ESCs in a physically confined area and efficiently differentiate them into a highly enriched population of healthy and functional midbrain dopamine progenitors and midbrain dopamine neurons.
[Nature Protocols] |
|
|
|
| Scientists recapitulated epicardiogenesis using human iiPSCs and identified type II classical cadherin CDH18 as a biomarker defining lineage specification in human active epicardium.
[NPJ Regenerative Medicine] |
|
|
|
| By leveraging recent knowledge of the signaling pathways involved in liver development, the authors described a robust, scalable protocol that allowed them to consistently generate high-quality bipotent human hepatoblasts and hepatocyte-like cells from both ESCs and iPSCs.
[Stem Cell Reports] |
|
|
|
| Researchers used two forms of hiPSC-derived HMOX1-reporter renal organoids to probe their ability to detect nephrotoxicants in a panel of blind-coded compounds.
[iScience] |
|
|
|
| Scientists performed frequent in situ monitoring of dissolved O2 and CO2 with optical sensor spots and contemporaneous evaluation of cell proliferation and medium pH in standard batch cultures of three widely used human somatic and PSC lines.
[Communications Biology] |
|
|
|
| Using hiPSC-derived retinal organoids, the authors identified the time-dependent role of mammalian target of rapamycin complex 1 (mTORC1) in retinal development, specifically in retinal ganglion cell differentiation and the retinal lamination process, during the early stages of retinal organoid development.
[Cell Death Discovery] |
|
|
|
| Investigators reported the generation of neurospheres from iPSC-derived neural progenitor cells and showed that these cultures were permissive to retroviral replication.
[Scientific Reports] |
|
|
|
| Researchers established motor nerve organoids from human PSCs with properties similar to those of neuromesodermal progenitors, a population of progenitor cells that comprise the caudal spinal cord.
[Scientific Reports] |
|
|
|
|
| The authors outline advances in iPSC modeling and therapeutic development for cardinal neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease.
[Cell Stem Cell] |
|
|
|
| Scientists provide a systematic overview of the progress and remaining challenges for the generation of non-human primate iPSCs/ESCs for the preclinical testing and validation of cell replacement therapies.
[Neural Regeneration Research] |
|
|
|
|
| The Paul G. Allen Frontiers Group, a division of the Allen Institute, announced 11 awards of $1.3-1.5 million each to fund research projects led by 23 new Allen Distinguished Investigators.
[Allen Institute] |
|
|
|
|
| February 24 – February 25, 2022
Virtual |
|
|
|
|
|
| | Francis Crick Institute – London, England, United Kingdom |
|
|
|
| | IRB Barcelona – Barcelona, Spain |
|
|
|
| | University of Nottingham – Nottingham, England, United Kingdom |
|
|
|
| | National University of Ireland Galway – Galway, Ireland |
|
|
|
| | Massachusetts General Hospital – Boston, Massachusetts, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
