 | | Vol. 17.06 – 16 February, 2022 |
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| Researchers reported that BEND3 was a CpG island (CGI) binding protein enriched at regulatory elements. Bend3 null ESCs exhibited severe defects in differentiation, during which hundreds of CGI-containing bivalent genes were prematurely activated.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed whole-genome sequencing of 143 hESC lines and annotated their single-nucleotide and structural genetic variants.
[Cell Stem Cell] |
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| Investigators reported a transcription initiation-centric, in-depth characterization of the transposon-derived regulatory landscape of mESCs.
[Nucleic Acids Research] |
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| Scientists developed a CRISPR activation iPSC platform that constitutively expressed the dCas9-VPR system, which allowed robust activation of the proneural transcription factor NEUROD1 to rapidly induce neuronal differentiation within seven days.
[ACS Applied Materials & interfaces] |
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| The authors investigated the use of human iPSCs and ESCs to develop a source of endothelial colony-forming cells-like cells for vascular repair.
[Leukemia] |
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| Researchers developed an iPSC-based neural crest-Schwann cell in vitro differentiation system and constructed a lineage expression roadmap for the analysis of different 2D and 3D neurofibroma models.
[Cell Reports] |
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| Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Scientists probed the potential links among these cancer traits by inactivating TP53 in hESCs.
[Cell Reports] |
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| Investigators showed that heterochromatin protein 1 (HP1) interaction-defective mutants of H3K9 MTs, Suv39h1 and Setdb1, underwent protein degradation. They further established mESC lines lacking all three HP1 paralogs.
[EMBO Reports] |
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| Scientists generated embryoid bodies from iPSCs using a strong mixed-pool study design and performed single-cell RNA-seq profiling.
[eLife] |
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| Retinal organoids produced from rhesus monkey iPSCs using established protocols differentiated through the stages of organoid development faster than those derived from human stem cells.
[Cell Proliferation] |
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| The authors developed a chemically synthetic culture substrate for hPSC attachment and maintenance. The substrate comprised a hydrophobic polyvinyl butyral-based polymer and a short peptide that enabled easy and uniform coating of various types of cell culture ware.
[Scientific Reports] |
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| Scientists developed a homozygous NaV1.5 KO iPSC line able to differentiate into cardiomyocytes with CRISPR/Cas9 tool. The NaV1.5 KO iPSC-cardiomyocytes exhibited an organized contractile apparatus and spontaneous contractile activity.
[Scientific Reports] |
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| Researchers engineered a new iPSC line in which the Förster resonant energy transfer (FRET) tension sensor was knocked into the endogenous vinculin locus, which permitted consistent native levels of vinculin expression in all cells.
[Biophysical Journal] |
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| Scientists provide a comprehensive overview of the different iPSCs to chondrocytes differentiation approaches, the hitherto described iPSC-chondrocyte disease models and mechanistic and/or therapeutic insights that have been derived from their investigation.
[Journal of Bone and Mineral Research] |
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| The authors highlight the recent progress on the role of endoplasmic reticulum and mitochondria in maintaining PSCs redox status, focusing on metabolism.
[Stem Cell Reviews and Reports] |
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| SEngine Precision Medicine, Inc. and Oncodesign announced the signature of a research collaboration agreement for R&D of a new personalized cancer treatment for aggressive and untreatable tumors.
[SEngine Precision Medicine, Inc. (Globe Newswire, Inc.)] |
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| March 15 – 20, 2022
Barcelona, Spain & Online |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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| | Cancer Research UK – Glasgow, Scotland, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | IRB Barcelona – Barcelona, Spain |
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| | University of Nottingham – Nottingham, England, United Kingdom |
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