 | | Vol. 17.07 – 23 February, 2022 |
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| Researchers investigated the mechanical basis of epiblast and primitive endoderm sorting. They found that rather than the differences in static cell surface mechanical parameters as in classical sorting models, it was the differences in surface fluctuations that robustly ensured physical lineage sorting.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that viral delivery of GDNF to the striatum, in conjunction with homotopic transplantation of human pluripotent stem-cell-derived midbrain dopamine (mDA) neurons, recapitulates brain-wide mDA target innervation.
[Cell Stem Cell] |
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| Oct4 linker mutant ESCs showed decreased expression of self-renewal genes and increased expression of differentiation genes, resulting in impaired ESC self-renewal and early embryonic development.
[Science Advances] |
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| Investigators developed a system for the production of platelet precursor cells, megakaryocytes, from PSCs. These cultures could be maintained for greater than 100 days, implying culture renewal by megakaryocyte progenitors.
[Science Advances] |
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| The authors used hiPSCs along with CRISPR-Cas9 gene editing to investigate the contribution of chromosome 21 candidate genes to Alzheimer’s disease-relevant neuronal phenotypes.
[Molecular Psychiatry] |
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| Using a variety of genetic and imaging approaches, researchers uncovered that in the mouse E6.5 epiblast, where apical tension is highest, ASPP2 safeguarded tissue integrity.
[Nature Communications] |
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| Scientists found that Dicer-deficient ESCs had strong proliferation and chromosome segregation defects as well as increased transcription of centromeric satellite repeats, which triggered the interferon response.
[Nature Communications] |
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| Investigators developed a tool, named BrewerIX, that provided comprehensive information about the allelic expression of a large, manually-curated set of imprinted and X-linked genes.
[Communications Biology] |
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| The authors reported the characteristics and function of mitochondria during human definitive endoderm differentiation.
[Cell Death Discovery] |
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| Scientists analyzed the transcriptome of cancer stem cells, which were converted from iPSCs with conditioned medium from pancreatic ductal adenocarcinoma cells.
[Scientific Reports] |
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| Researchers established various human cell lines with human artificial chromosomes/mouse artificial chromosomes that harbored a gene-loading site via microcell-mediated chromosome transfer.
[Scientific Reports] |
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| To elucidate the polygenic architecture of Alzheimer’s disease (AD) phenotypes at a cellular level, investigators established iPSCs from 102 patients with AD, differentiated them into cortical neurons, and conducted a genome-wide analysis of the neuronal production of amyloid β (Aβ).
[Nature Aging] |
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| The authors describe the reconstitution of primordial germ cells and the subsequent meiosis, as well as the signaling pathways and factors involved in these processes.
[Stem Cell Research & Therapy] |
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| Once the main hurdles to stem cell-based therapies are overcome, translation to clinical practice will greatly improve the quality of life of people with type 1 diabetes mellitus.
[European Journal of Pharmaceutical Sciences] |
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| City of Hope’s Department of Stem Cell Biology and Regenerative Medicine has received a $4.9 million grant to train the next generation of scientific leaders in basic stem cell research and its translation into novel, lifesaving treatments.
[City of Hope] |
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| April 7 – April 9
Rome, Italy & Virtual |
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| | University of Lausanne – Lausanne, Switzerland |
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| | University Hospital Bonn – Bonn, Germany |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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| | Cancer Research UK – Glasgow, Scotland, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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