 | | Vol. 17.09 – 9 March, 2022 |
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| Scientists employed DNA fiber analysis to investigate how PSCs were reprogrammed into totipotent-like 2-cell-like cells (2CLCs) and showed that totipotent cells of the early mouse embryo had slow DNA replication fork speed and that 2CLCs recapitulated this feature.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Transcriptomic analysis showed that differentiation of hiPSCs derived from diabetics into KDR+CD56+APLNR+ (KNA+) cells was sufficient to change baseline differences in gene expression caused by the diabetic status and reprogram diabetic cells to a pattern similar to KNA+ cells.
[Science Advances] |
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| Researchers established an in vitro iPSC model of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B cell lymphoma and examined whether doxorubicin-treated ACT-iPSC cardiomyocytes could recapitulate the clinical features exhibited by patients.
[Basic Research in Cardiology] |
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| Through high-resolution 3D-structured illumination microscopy and functional analysis, investigators reported multiple biological processes associated with the meiosis-specific cohesin components, α-kleisin REC8 and STAG3, and the distinct loss of function of meiotic cohesin during the cell cycle of ESCs.
[Genome Biology] |
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| The authors established a new hiPSCs line derived from amniotic cells of a fetus with a homozygous β41-42 deletion mutation in the HBB gene and a heterozygous Westmead mutation in the HBA2 gene. They designed a CRISPR-Cas9 to target these casual mutations and corrected them.
[Stem Cell Research & Therapy] |
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| Researchers transplanted cells that were generated from hiPSCs into regionally specific spinal neural progenitor cells utilizing a novel accelerated differentiation protocol designed for clinical translation.
[Journal of Cellular and Molecular Medicine] |
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| Investigators found that the limited expansion of ESC CD34+ cell-derived erythroid cells was associated with defective cell cycle of erythroid progenitors.
[Journal of Cellular and Molecular Medicine] |
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| Scientists developed a method to generate photoreceptor cells (PRCs) from human iPSCs by introducing the transcription factors CRX and NEUROD1, which enabled them to generate induced photoreceptor-like cells expressing PRC markers.
[iScience] |
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| The authors mimicked histone H3 at the 56th lysine (H3K56) mutant incorporation in mESCs by lentivirus-mediated ectopic expression and analyzed the effects on replication and epigenetic regulation.
[Journal of Molecular Cell Biology] |
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| To rescue the functionally extinct species of the northern white rhinoceros, investigators employed iPSCs to generate gametes and subsequently embryos in vitro.
[Scientific Reports] |
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| Researchers characterized the progression and the cellular mechanisms involved in α-synuclein pre-formed fibrils transfer from enteroendocrine cells to neuronal cells.
[Scientific Reports] |
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| Scientists discuss current methods and their limitations for producing nonhuman primate genetic models that faithfully genocopy and phenocopy human disease.
[Science Translational Medicine] |
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| The authors discuss the latest research on long non-coding RNAs in iPSC stemness, neuronal, and cardiac differentiation.
[American Journal of Physiology-Cell Physiology] |
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| Alchemab Therapeutics announced an extension of its collaboration with Medicines Discovery Catapult, a national facility enabling the UK’s community to accelerate innovative drug discovery.
[Alchemab Therapeutics] |
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| March 20 – 25, 2022
Vienna, Austria |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States |
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| | Oregon Health and Science University – Portland, Oregon, United States |
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| | University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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