 | | Vol. 17.10 – 16 March, 2022 |
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| Researchers identified a non-canonical tricarboxylic acid (TCA) cycle that was required for changes in cell state. During exit from pluripotency, ESCs switched from canonical to non-canonical TCA-cycle metabolism.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported that iPSCs reprogramed from CD62L+ naive and memory T cells followed by CD19-CAR engineering and 3D-organoid system differentiation conferred products with conventional CD8αβ-positive CAR T cell characteristics.
[Cell Stem Cell] |
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| By targeting 1,700 transcription factors with CRISPR loss-of-function screen, researchers found that ZBTB11 and ZFP131 were required for ESC pluripotency.
[Cell Reports] |
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| Scientists used cerebral organoids derived from patients and genome edited-iPSCs to address pathophysiological changes associated with a complex malformation of human cortical development caused by mutations in the echinoderm microtubule-associated protein-like 1 (EML1) gene.
[EMBO Reports] |
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| By screening a fluorescent probe library, investigators found that intracellular glycogen led to specific reactivity to CDg4, a glycogen fluorescence sensor, in both human and mouse naïve ESCs.
[Metabolic Engineering] |
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| The authors generated ten O-negative hiPSC clones and evaluated their potential for mesoderm formation and erythroid differentiation, then used a perfusion bioreactor system to perform studies with high-density cultures of erythroblasts in vitro.
[Cell Proliferation] |
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| Researchers generated iPSC-derived hepatocytes and iPSC-derived cholangiocytes cells and characterized them based on hepatocyte-specific and cholangiocyte-specific markers.
[Hepatology Communications] |
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| The authors established a robust method allowing rapid derivation of mesenchymal stem cells from both human iPSCs and ESCs via a temporal induction of neural ectoderm in chemically defined media.
[Cell & Bioscience] |
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| To identify embryotoxic compounds, scientists developed an hiPSC-based biomarker assay based on the differentiation of hiPSCs into functional cardiomyocytes and hepatocytes.
[Birth Defects Research] |
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| Researchers reported that depletion of Jmjd6 not only resulted in downregulation of pluripotency genes, but was also implicated in apoptosis, glycolysis, cell cycle and protein hydroxylation.
[Heliyon] |
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| Scientists describe how differentiation of hiPSCs to specialized cardiac cellular identities facilitates our understanding of the development and pathogenesis of congenital heart disease subtypes.
[Birth Defects Research] |
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| The authors indicate that GD3 synthase contributes to gefitinib resistance in epidermal growth factor receptor-positive breast cancer cells, and is a potentially useful therapeutic target in drug-resistant breast cancers.
[Glycoconjugate Journal] |
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| Promega Corporation and FUJIFILM Cellular Dynamics, Inc., a leading global developer and manufacturer of human iPSC technologies, announced a strategic collaboration to advance novel assay development for drug discovery.
[Promega Corporation] |
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| I Peace, Inc. announced that the company had tripled its capacity to manufacture GMP grade iPSCs and iPSC-derived differentiated cells by expanding its facility.
[I Peace, Inc. (Cision US, Inc.)] |
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| May 19 – 22, 2022
Cancun, Mexico |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States |
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| | Oregon Health and Science University – Portland, Oregon, United States |
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