 | | Vol. 17.11 – 23 March, 2022 |
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| Researchers established an hiPSC-derived epithelial and mesenchymal organoid model in a 3D culture system for localized scleroderma therapy.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors established DamID- and HiC-based methodologies to generate accurate genome-wide maps of nucleolar associated domains in ESCs and neural progenitor cells, revealing layers of genome compartmentalization with distinct, repressive chromatin states.
[Nature Communications] |
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| Scientists described a protocol that can be adopted by those seeking to create clinical-grade iPSC from banked cord blood. Cells were maintained in a feeder-free, xeno-free environment, using fully defined, commercially available reagents.
[Frontiers in Cell and Developmental Biology] |
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| Researchers constructed a stemness index for single-cell samples (StemSC) based on relative expression orderings of gene pairs.
[Stem Cell Research & Therapy] |
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| To study the impact of triiodothyronine on hPSCs, cell survival and growth were evaluated by measurement of cell growth curve, cloning efficiency, survival after passaging, cell apoptosis, and cell cycle status.
[Stem Cell Research & Therapy] |
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| Investigators applied high-dimensional design of experiments methodology to identify critical process parameters that govern neural territory patterning from pluripotency — the first stage toward the specification of central nervous system cell fates.
[iScience] |
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| Researchers showed that induced human DUX4 expression substantially altered the chromatin accessibility of non-coding DNA and activated thousands of newly identified transcribed enhancer-like regions, preferentially located within ERVL-MaLR repeat elements.
[iScience] |
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| By promoting matrix-supported active cell reaggregation, the authors engineered multiregional cerebral tissues with intact 3D neuronal networks and functional interconnectivity characteristic of brain networks.
[Communications Biology] |
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| Scientists characterized non-endocrine cells in iPSC-derived pancreatic islet cells using single-cell transcriptomic analysis and found that non-endocrine cells consisted of heterogeneous proliferating cells, and cells with not only pancreatic traits but also liver or intestinal traits marked by FGB or AGR2.
[Scientific Reports] |
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| Researchers designed a workflow to reproducibly extract proteins from brain organoids, measure global turnover using mass spectrometry, and statistically investigate turnover differences between genotypes.
[Methods] |
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| The authors evaluate several of the ongoing and future directions of combining next-generation CRISPR-Cas9 gene editing with synthetic biology to optimize chimeric antigen receptor (CAR) T cell therapy for future clinical trials toward the establishment of a new cancer treatment paradigm.
[Molecular Cancer] |
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| Scientists review various modalities to evaluate the function of human stem cell-derived cardiac tissues and introduce heart-on-a-chip systems that can recapitulate physiological parameters of hPSC-derived cardiac tissues.
[Stem Cells] |
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| Investigators provide a brief overview of protocols that have laid the foundation for derivation of stem cell-derived 3D cardiac models.
[BMC Cardiovascular Disorders] |
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| The Lundquist Institute’s investigator Dr. Eiji Yoshihara has received a five-year $749,995.50 Career Development Award from the Juvenile Diabetes Research Foundation for his proposed study on how human β cells gain immune evasive function by environmental cues.
[The Lundquist Institute (Cision US, Inc.)] |
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| | Mayo Clinic – Jacksonville, Florida, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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