 | | Vol. 17.12 – 30 March, 2022 |
| |
|
|
| Investigators showed that the rixosome contributed to the silencing of many Polycomb targets in human cells and that it was associated with human Polycomb repressive complexes and was enriched at promoters of Polycomb target genes.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors devised a screening strategy and identified small molecules that bound the non-coding RNA prototype Xist. The X1 compound had drug-like properties and bound specifically the RepA motif6 of Xist in vitro and in vivo.
[Nature] |
|
|
|
| Researchers showed that patterned organoids and bioprinted tissues with controlled composition and organization could be generated by simultaneously co-differentiating hiPSCs into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.
[Nature Biomedical Engineering] |
|
|
|
| Scientists used genome-wide screening to identify essential regulators as well as major impediments of human primed to naïve PSC reprogramming.
[Science Advances] |
|
|
|
| Investigators reported a replenishable female mESC system, Xmas, that allowed rapid assessment of X chromosome inactivation, the epigenetic silencing mechanism of one of the two X chromosomes that enabled dosage compensation in female mammals.
[Nature Communications] |
|
|
|
| To obtain a better appreciation of the molecular processes during the differentiation of iPSCs into hepatocytes, researchers employed a quantitative proteomic approach to follow the expression of 9,000 proteins, 12,000 phosphorylation sites, and 800 acetylation sites over time.
[Cell Reports] |
|
|
|
| Scientists found that the depletion of Rif1 broke down the barrier to the transition from ESCs to trophoblast stem cells.
[Cell Reports] |
|
|
|
| The authors used a forward genetic approach with mouse haploid ESCs to generate high-throughput mutant libraries, from which numerous oxidative stress-targeting genes were screened out.
[Cell Death & Disease] |
|
|
|
| Researchers presented a dataset of microelectrode array recordings from hPSC-derived and rat embryonic cortical neurons during their in vitro maturation.
[Scientific Data] |
|
|
|
| Investigators developed a dual SHOX2:GFP; MYH6:mCherry knock-in hESC reporter line, which allowed for the identification and purification of sinoatrial node (SAN)-like cells.
[iScience] |
|
|
|
| Scientists showed that the hepatic functions of hPSC-hepatocyte-like cells were facilitated by applying physiological liver temperatures during hepatic differentiation.
[Scientific Reports] |
|
|
|
|
| The authors describe high-throughput analysis of crucial parameters related to mitochondrial function in hiPSC-derived neurons.
[Methods in Molecular Biology] |
|
|
|
| Scientists review the potential of synthetic electrospun scaffolds in osteogenic differentiation of iPSCs and address approaches to improve the osteogenic differentiation of these scaffolds.
[Journal of Biomaterials Science-Polymer Edition] |
|
|
|
|
| Vyant Bio, Inc. and OrganoTherapeutics announced they have entered into a collaboration agreement to work toward accelerating the discovery of drugs for the treatment of Parkinson’s Disease.
[Vyant Bio, Inc.] |
|
|
|
|
| May 25 – 27, 2022
Hinxton, England, United Kingdom |
|
|
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| | Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| | Mayo Clinic – Jacksonville, Florida, United States |
|
|
|
| | University of California, San Diego – La Jolla, California, United States |
|
|
|
| | Genentech, Inc. – South San Francisco, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
