 | | Vol. 17.14 – 13 April, 2022 |
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| The authors demonstrated, by creating an intermediate plastic state, the chemical reprogramming of human somatic cells to human chemically iPSCs that exhibited key features of ESCs.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated the induction of functional primordial germ cell–like cells (PGCLCs) from rat PSCs. They showed that epiblast-like cells in floating aggregates formed rat PGCLCs.
[Science] |
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| Investigators observed that the initiation of differentiation in iPSCs and ESCs triggered widespread apoptosis, followed by a synchronous epithelial–mesenchymal transition.
[Nature Cell Biology] |
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| Scientists reported an 18-year-old patient with ultrarare Leigh-like syndrome. They established an iPSC–based platform for this patient, and assessed the efficacy of a panel of drugs.
[Science Advances] |
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| Researchers reported that deadenylase Cnot8 of Ccr4-Not complex played essential roles during the transition from naïve to formative state. Knock out (KO) Cnot8 resulted in early embryonic lethality in mice, but Cnot8 KO ESCs could be established.
[Nucleic Acids Research] |
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| Investigators used a mESC model to describe in detail the relationships within the H3K27-H3K36-DNA methylation subnetwork, particularly the major epigenetic reorganization caused by deletion of the histone 3 lysine 36 methyltransferase NSD1, which in mESCs deposits nearly all of the intergenic H3K36me2.
[Genome Research] |
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| The authors derived patient hiPSC-cardiomyoctyes (CMs) carrying compound mutations in the adult SCN5A exon 6B and exon 4. Electrophysiological properties of patient hiPSC-CMs in monolayer were not altered by the exon 6B mutation compared to isogenic controls since it was not expressed.
[Cardiovascular Research] |
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| COXPD23 caused by mutations in GTPBP3 gene is a rare mitochondrial disease. The patient-derived PBMCs of a sibling with the compound heterozygous variants in GTPBP3: c.1289G>A; c.545G>A were reprogrammed into iPSC lines using non-integrative Sendai virus.
[Stem Cell Research] |
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| Scientists generated an iPSC line from the peripheral blood mononuclear cells of an otosclerosis patient. The cell line exhibited normal morphology, karyotype, and pluripotency marker expression.
[Stem Cell Research] |
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| The embryonic development process and the pro-myogenic role of the muscle-resident cell populations in co-cultures are described, highlighting the possible clinical applications of iPSCs in the skeletal muscle tissue engineering field.
[NPJ Regenerative Medicine] |
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| The authors focus on how to progress in vitro generation of platelets from stem cell, especially iPSCs, and describe some of the successful strategies that can be easily used in clinic.
[Stem Cell Reviews and Reports] |
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| Japan-based National University Corporation Osaka University, Shimadzu Corporation, and SIGMAXYZ, Inc. have signed an agreement on collaboration for social implementation of 3D bioprinting technology.
[BioSpectrum] |
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| June 15 – 18, 2022
San Francisco, California, United States |
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| | Harvard University – Cambridge, Massachusetts, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Novo Nordisk – Fremont, California, United States |
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| | RIKEN Center for Brain Science – Tokyo, Japan |
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