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| Investigators showed that human PSCs edited via CRISPR to knock out the kinesin-2 subunits KIF3A or KIF3B could be used to model ciliopathy phenotypes and to reveal ciliary functions at the tissue scale.
[Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported the generation of human somitoids, organoids that periodically formed pairs of epithelial somite-like structures.
[Nature Communications] |
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| Researchers demonstrated that mice lacking the SET domain of Set1A were embryonic lethal at a stage that wasunique from null alleles.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators generated hiPSC-derived keratinocytes from patients carrying KRT5 dominant mutations and compared them to non-affected hiPSC-derived keratinocytes as well as their primary counterparts.
[Journal of Investigative Dermatology] |
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| Investigators derived iPSCs from peripheral blood erythroblasts obtained from patients diagnosed with immune aplastic anemia using non-integrating plasmids to model the disease.
[Cell Death & Disease] |
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| Researchers directed stable hiPSC-derived neuroepithelial stem cells to human iPSC-derived astrocytes with a high percentage of star-shaped cells by orchestrating an astrocytic-tuned culturing environment in 28 days.
[Stem Cell Reviews and Reports] |
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| Researchers investigated the expression of microRNAs in hiPSC cardiomyocytes in response to a broad range of cardiotoxic drugs.
[Archives of Toxicology] |
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| Scientists established a human iPSC, derived from a patient with dilated cardiomyopathy carrying a nonsense mutation in LMNA.
[Stem Cell Research] |
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| The authors investigated the mechanism underlying drug resistance in T cell acute lymphoblastic leukemia (T-ALL) using the T-ALL-derived iPSCs model.
[Cancer Medicine] |
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| Scientists review the mechanisms by which early embryonic cavities are formed and discuss the cavities in terms of their common and stage-specific principles of lumenogenesis and their functions.
[Seminars in Cell & Developmental Biology] |
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| Accelerated Biosciences announced an agreement for Pluristyx, Inc. to provide iPSCs derived from human trophoblast stem cells procured under Good Tissue Practices for research evaluation.
[Accelerated Biosciences (BioSpace, Inc.)] |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Singapore – Singapore, Singapore |
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| | Harvard University – Cambridge, Massachusetts, United States |
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| | Helmholtz Munich – München, Germany |
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