 | | Vol. 17.21 – 1 June, 2022 |
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| Scientists discovered that polycomb repressive complex 2 maintained naïve pluripotency and restricted differentiation to trophectoderm and mesoderm lineages.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using synthetic biology and tissue engineering, the authors developed and tested genetically engineered cartilage from murine iPSCs capable of preserving the circadian clock in the presence of inflammation.
[Science Advances] |
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| Researchers outlined an approach for high-yield derivation of mesencephalic dopamine neurons that principally differed from alternative technologies by utilizing retinoic acid signaling, instead of WNT and FGF8 signaling, to specify mesencephalic fate.
[Nature Communications] |
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| Scientists utilized iPSC-derived human brain microvascular endothelial cells to study virus-blood-brain barrier interactions.
[Cell Reports] |
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| To establish mature myotubes, researchers avoided the forced expression of specific genes by purifying hiPSC-derived muscle stem cells by Pax7-fluorescence monitoring and antibody sorting.
[Frontiers in Cell and Developmental Biology] |
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| The authors generated an allelic series of clonal isogenic hESC lines expressing a broad range of α-Synuclein, including lines expressing the protein at supraphysiological levels.
[Frontiers in Cell and Developmental Biology] |
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| Investigators optimized the protocol for Good Manufacturing Practice compatible CRISPR-Cas9 genome editing to deplete the three gene locus, HLA-A, HLA-B, and CIITA genes, simultaneously in human leukocyte antigen homozygous iPSCs.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists derived iPSCs from fibroblasts of Wisconsin miniature swine (WMS), Yucatan miniature swine (YMS), and Göttingen minipigs (GM) using their culture medium. YMS fibroblasts were more efficiently reprogrammed into iPSCs, forming colonies with well-defined borders, than WMS and GM fibroblasts.
[Scientific Reports] |
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| Researchers investigated the cause of diverse non-infectious neurologic abnormalities, in which iPSCs from two purine nucleoside phosphorylase-deficient patients were differentiated into neurons.
[Scientific Reports] |
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| Investigators demonstrated an efficient workflow for feeder-free single-cell clone generation and expansion in both CRISPR-mediated knock-out and knock-in hiPSC lines.
[Molecular Biology Reports] |
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| The authors review the current advances in the field of hPSC culturing, advantages, and challenges in bioreactor use, and regulatory areas of concern with respect to these advances.
[Cell Proliferation] |
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| Tiffany Dang, a University of Calgary (UCalgary) PhD student who has always wanted to work in the health field, found her calling after completing her undergraduate degree in chemical engineering, with a specialization in biomedical engineering.
[University of Calgary] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Cleveland Clinic – Cleveland, Ohio, United States |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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| | Stem Cell Network – Ottawa, Ontario, Canada |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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