 | | Vol. 18.14 – 12 April, 2023 |
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| Scientists reported that constitutive elimination of both MLL3 and MLL4 enzymatic activities prevented initiation of gastrulation and led to early embryonic lethality in mice.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used CRISPR-Cas9–mediated gene editing in Caenorhabditis elegans to investigate the expression pattern and role of individual replication-coupled histone H3 genes and compare them to the histone variant, H3.3.
[Science Advances] |
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| The authors showed that adult stem cells in the cnidarian Hydractinia symbiolongicarpus were pluripotent. They transplanted single i-cells from transgenic fluorescent donors to wild-type recipients and followed them in vivo in the translucent animals.
[Current Biology] |
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| Researchers generated a single-cell RNA sequencing reference of mouse in vivo cardiomyocyte maturation with extensive sampling of previously difficult-to-isolate perinatal time periods.
[Cell Reports] |
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| Scientists developed the dCas9-KRAB-MeCP2 fusion protein for screening in iPSCs from multiple donors. They found silencing in a 200 bp window around the transcription start site in polyclonal pools to be as effective as using wild-type Cas9 for identifying essential genes, but with much reduced cell numbers.
[Stem Cell Reports] |
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| Following principles of developmental biology and translational applicability, investigators developed an efficient stepwise differentiation method for peptidergic and non-peptidergic nociceptors.
[Stem Cell Reports] |
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| The authors generated a Upf3a conditional knockout mouse strain and established multiple lines of ESCs and somatic cells without UPF3A. UPF3A neither repressed nonsense-mediated mRNA decay in mouse ESCs, somatic cells, nor in major organs including the liver, spleen, and thymus.
[Life Science Alliance] |
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| Researchers showed that engineered alignment, incorporated before and during cardiac differentiation, affected hiPSC-cariomycotytes electrochemical coupling and mitochondrial morphology.
[Tissue Engineering Part A] |
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| The authors investigated the role of crotonylation in hESC differentiation by introduce crotonate into the culture medium of GFP tagged LTR7 primed H9 cell and extended PSC lines.
[Stem Cell Research & Therapy] |
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| Investigators examined the state of the art of available cloning technologies and their progress in species other than humans and rodent models, in order to provide a critical overview of their readiness and relevance for application in endangered animal conservation.
[Biological Reviews] |
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| The authors discuss their applications in studies of regulatory mechanisms involved in early developmental processes, including identification of molecular features, X chromosome inactivation modeling, transposable elements regulation, metabolic characteristics, and cell fate regulation.
[Cell Reports] |
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| Differentiation protocols to form bona fide bone-forming from iPSCs are available, and can be used to probe details of differentiation and function in depth.
[Bone] |
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| The California Institute for Regenerative Medicine will provide more than $2.6 million in total funding for two major stem cell research projects led by scientists at UC Santa Cruz, the organization announced.
[UC Santa Cruz] |
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| May 28 – 31, 2023
Killarney, Ireland |
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| | Universit̩ de Lausanne РLausanne, Switzerland |
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| | STEMCELL Technologies Inc. – Vancouver, British Columbia, Canada |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | The University of Utah – Salt Lake City, Utah, United States |
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| | King’s College London – London, England, United Kingdom |
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