 | | Vol. 17.23 – 15 June, 2022 |
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| A simple 3D culture system that allowed the generation and manipulation of neuroepithelial (NE) organoids from hiPSCs, displaying developmental phases of hiPSC differentiation and self-aggregation, first into NE cysts with lumen structure and then toward NE organoids with floor-plate patterning, was established.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that the catalytic activity of the glycolytic enzyme Enolase 1 was directly regulated by RNAs leading to metabolic rewiring in mESCs.
[Molecular Cell] |
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| Researchers screened murine cell types present in the developmental or adult stem cell niche in heterotypic suspension embryoids and identified embryonic endothelial cells and fibroblasts as highly permissive for myogenic specification of hiPSCs.
[EMBO Journal] |
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| Investigators examined the roles of inhibition of DNA binding protein 1 (ID1) and ID3 and in primed and naive-like hESCs and showed that ID1 and ID3 knockout lines exhibited decreased survival in both primed and naive-like state.
[Cell Death & Disease] |
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| Researchers developed a technology that combined miRNA-responsive mRNA switch (miR-switch) with miR-switch-magnetic-activated cell sorting to purify large amounts of PSC-derived cells rapidly and effectively.
[Stem Cell Reports] |
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| Scientists established a robust hiPSC-endothelial cells (ECs) differentiation protocol that was cost-effective, highly reproducible, avoided the use of animal-derived media compounds, and yielded highly pure human ECs.
[Stem Cell Research & Therapy] |
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| Using the non-integrating Sendai virus to deliver the Klf4, OCT3/4, SOX2 and C-MYC factors, fibroblasts obtained from a neuronal intranuclear inclusion disease patient were reprogrammed to generate an iPSC line.
[Stem Cell Research] |
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| Researchers presented the generation and characterization of an iRFP720 expressing hiPSC line, which could be used for real-time imaging in various biological applications.
[Scientific Reports] |
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| The authors reported that the homeobox-containing transcription factor HESX1 played a critical role in the mesendodermal commitment of hESCs.
[Biochemical and Biophysical Research Communications] |
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| Understanding the metabolic requirements of PSCs is instrumental for their efficient generation, expansion, and differentiation.
[Current Opinion in Genetics & Development] |
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| The authors summarize the progress on the derivation of porcine PSCs and reprogrammed cells and elucidate the mechanisms of pluripotency changes during pig embryo development.
[Biology of Reproduction] |
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| Umoja Biopharma, Inc. and TreeFrog Therapeutics announced that they have entered into a collaboration to evaluate Umoja’s iPSC platform within TreeFrog’s C-Stem™ technology for scalable expansion and immune cell differentiation in bioreactors.
[Umoja Biopharma, Inc.] |
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| December 8 – 10, 2022
Los Angeles, California, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Flanders Institute for Biotechnology – Antwerp, Belgium |
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| | University College London – London, England, United Kingdom |
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| | Uppsala University – Uppsala, Sweden |
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| | Francis Crick Institute – London, England, United Kingdom |
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