 | | Vol. 17.25 – 29 June, 2022 |
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| Investigators demonstrated induction and long-term maintenance of totipotent stem cells from mPSCs by a combination of three small molecules, TTNPB, 1-Azakenpaullone, and WS6.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers designed and verified an induced CTCF phase separation system in ESCs, which facilitated inter-A compartment interactions, improved self-renewal of ESCs, and inhibited their differentiation toward neural progenitor cells.
[Cell Research] |
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| Scientists evaluated the link between G1/S restriction point activation, phasic gene expression, and cellular differentiation.
[Nature Communications] |
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| Investigators showed that upon iPSC differentiation into neural progenitor cells, the deletion of 22q11.2 acted in trans to alter the abundance of transcripts associated with risk for neurodevelopmental disorders including autism.
[Nature Communications] |
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| KCNQ1 was knocked out in the hESC H9 line using the CRISPR/cas9 system. KCNQ1-deficient and KCNQ1-mutant hESCs were differentiated into cardiomyocytes through a chemically defined differentiation protocol.
[Stem Cell Research & Therapy] |
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| Researchers reported a novel culture system for hematopoietic differentiation from hESCs with optimal cytokines combinations under hypoxia conditions.
[Stem Cell Research & Therapy] |
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| HDAC inhibitors and proteasome inhibitors induced heat shock protein 90 (HSP90) cleavage in the mouse ESC line R1, and the cleaved HSP90 was barely found in the cells and instead secreted out of the cells through the exosome.
[Biochemical and Biophysical Research Communications] |
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| Scientists investigated the culture-induced changes in passaged fetal retinal pigment epithelium (RPE), hESC-RPE, and hiPSC-RPE cells and explored the differentiation and maturation effect of all-trans retinoic acid on cells for manufacturing and screening high quality RPE cells for clinical transplantation.
[Current Eye Research] |
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| The authors prepared human leukocyte antigen (HLA)-matched iPSCs using HLA common haplotype homozygous donors from cryopreserved human cord blood sourced from the Tianjin Cord Blood Public Bank.
[Febs Open Bio] |
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| Scientists discuss the multifaceted role of ZSCAN4 in embryonic development, ESCs, iPSCs, cancer, and germ cells.
[Stem Cell Reviews and Reports] |
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| The authors review the current knowledge gained in understanding the molecular events involved in retinal disease using hPSC-derived retinal models, in particular retinal pigment epithelium models.
[Clinical & Experimental Ophthalmology] |
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| TreeFrog Therapeutics announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell biology and regenerative medicine.
[TreeFrog Therapeutics] |
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| The family of Kimberly Greenberg and H1-E Syndrome Foundation presented a $45,000 gift check to Dr. Jiang’s lab, which has succeeded in modeling H1-4 causing neurodevelopmental defects using human H1-4 patient-derived iPSC and brain organoids.
[Yale School of Medicine] |
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| November 7 – 8, 2022
London, England, United Kingdom |
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| | Uconn Health – Farmington, Connecticut, United States |
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| | European Molecular Biology Laboratory – Barcelona, Spain |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | The University of Arizona – Tucson, Arizona, United States |
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| | Yale University – New Haven, Connecticut, United States |
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