 | | Vol. 17.26 – 6 July, 2022 |
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| Gastric fundic, antral, and duodenal organoids were generated using iPSC lines from a PDX1188delC/188delC patient and an isogenic iPSC line where the PDX1 point mutation was corrected.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that the accumulation and mobilization of lipid droplets upon implantation were causal in the morphogenesis of the pluripotent epiblast and generation of the pro-amniotic cavity in mouse embryos.
[Nature Communications] |
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| A genomic survey of SETDB1 binding in mESCs across multiple libraries was conducted, leading to the unexpected discovery of regions bereft of common repressive histone marks.
[Nucleic Acids Research] |
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| The authors generated hiPSCs from a patient with rare mosaic HHT1 with tissues containing both mutant and normal cells, enabling the derivation of isogenic diseased and healthy hiPSCs, respectively.
[Stem Cell Reports] |
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| Researchers reported that a short-pulsed expression of DUX4 in primed hESCs activated an embryonic genome activation-like gene expression program in up to 17% of the cells, retaining cell viability.
[Stem Cell Reports] |
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| Scientists differentiated hiPSCs and hESCs into human mesenchymal stem cells (hMSCs) on dishes coated with different extracellular matrix proteins to study the effect of cell culture biomaterials on hPSC differentiation into hMSCs.
[Journal of Materials Chemistry B] |
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| The authors generated iPSCs lines from three patients with familial Parkinson’s disease associated with the G2019S mutation in the LRRK2 gene and one age-matched healthy individual.
[Frontiers in Neuroscience] |
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| Researchers used a fast-rotating 2D clinostat to investigate the simulated microgravity effect on proliferation, self-renewal, and cell cycle regulation of hPSCs.
[NPJ Microgravity] |
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| Scientists utilized a three-stage protocol to induce differentiation of mesoderm, vascular progenitors, and endothelial cells from hiPSCs and investigated the regulatory effects of histone acetylation on the differentiation processes.
[Cell Biochemistry and Function] |
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| The authors summarize mitochondrial functions and recent therapeutic discoveries, advancements, and limitations of using iPSC-cardiomyocytes to study mitochondrial diseases of the heart.
[Febs Letters] |
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| Inceptor Bio announced a collaboration with the University of Minnesota. The aim of this collaboration is to build a novel iPSC platform that will accelerate Inceptor Bio’s best-in-class next-generation cell therapies platforms.
[Inceptor Bio] |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | Babraham Institute – Babraham, England, United Kingdom |
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| | University of Oslo – Oslo, Norway |
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| | Uconn Health – Farmington, Connecticut, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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Cancer Stem Cell News
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