 | | Vol. 17.28 – 20 July, 2022 |
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| Scientists discovered that the DNA repair-related protein, 5-hydroxymethylcytosine binding, ESC specific (HMCES), contributed to early development by maintaining nodal/activin- or bone morphogenetic protein (BMP)-signaling-regulated transcriptional network.
[Cell Reports] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators genetically engineered hPSCs with synthetic chimeric antigen receptors and differentiated them into functional neutrophils by implementing a chemically defined platform.
[Cell Reports] |
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| Scientists showed that the interferon regulatory factor 1(Irf1) was directly controlled by the murine formative pluripotency gene regulatory network and transiently upregulated during the transition from naive to formative pluripotency.
[EMBO Reports] |
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| Researchers characterized mESC lines that continued to have m6A in their mRNA after Mettl3 knockout.
[PLoS Biology] |
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| The authors investigated the role of retinoic acid (RA) and Wnt signaling in the induction of sinus node-like cells.
[Stem Cell Research & Therapy] |
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| Using an isogenic pair of naïve and primed mESCs, investigators demonstrated the differential role of Src homology region 2 domain-containing phosphatase 2 (Shp2) in naïve and primed pluripotency.
[Stem Cell Research & Therapy] |
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| To understand how macrophages affected the behavior of iPSCs, researchers generated three macrophage subtypes and assessed their effects on the proliferation, cardiac differentiation, and maturation of iPSCs.
[Cell Communication and Signaling] |
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| The authors investigated the effect of miR-124a loss on neuronal differentiation in mice and in ESCs.
[Journal of Biological Chemistry] |
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| Scientists showed that survival motor neuron (SMN) was gradually upregulated in pre-implantation mouse embryos and cultured cells undergoing cell reprogramming.
[Stem Cells and Development] |
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| The authors focus on how epigenetic factors, including DNA methylation, bivalent chromatin, chromatin remodelers, chromatin/nuclear architecture, and miRNA, could dictate pluripotent states and their transition among themselves.
[Cell and Tissue Research] |
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| The American Society of Reproductive Medicine honored Professor Rachel West at Auburn University with the KY CHA Award in Stem Cell Technology for her contributions to the development of reproductive medicine.
[Business Wire, Inc.] |
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| November 10 – 12, 2022
Bordeaux, France |
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| | Institute for Cell Engineering – Baltimore, Maryland, United States |
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| | US Department of Health and Human Services – Research Triangle Park, North Carolina, United States |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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