 | | Vol. 17.29 – 27 July, 2022 |
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| Scientists utilized CRISPR-Cas9 gene editing to engineer novel isogenic hiPSC models, consisting of isogenic androgen receptor (AR) knockout, control, and disease lines expressing mutant AR with distinct repeat lengths.
[Brain] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To further expand hiPSC-derived cardiomyocytes’ (CMs) potential as a research tool and bridge the translational gap, investigators generated a cardiac-specific hiPSC reporter line that differentiated into fluorescent CMs using CRISPR-Cas9 genome editing technology.
[Cell Biology and Toxicology] |
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| iPSCs carrying a SYCP3-mkate2 knock-in reporter were generated by the CRISPR/Cas9 strategy to monitor meiosis status during induced differentiation from iPSCs into oocytes.
[Stem Cell Research & Therapy] |
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| Brain organoids were characterized regarding brain development, cell type composition, and Machado-Joseph disease-associated neuropathology markers, to evaluate their value for cerebellar diseases modeling.
[Scientific Reports] |
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| The authors combined iPSC-derived spinal motor neurons and microglia and established a novel co-culture, which was compatible with motor neuron identity and function.
[Scientific Reports] |
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| Scientists added Lin28, known as one of the reprogramming factors, in the form of a soluble recombinant protein from E. coli to improve the efficiency of hiPSC generation, in respect of alkaline phosphatase-positive colonies.
[Frontiers in Bioengineering and Biotechnology] |
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| Investigators established a novel ovarian granulosa cell (OGC)-derived iPSC cell line from the follicular fluid of a healthy female donor with a Chinese Han genetic background and named it IPS-OGC-C1.
[Human Cell] |
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| Through constructing inducible knockdown or overexpressing WDR36-human extended PSC (EPSC) lines, researchers found that WDR36 knockdown disrupted self-renewal but promoted the mesodermal differentiation of human EPSCs.
[Frontiers in Genetics] |
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| Scientists induced lubricin-expressing cells from iPSCs and applied them locally via cell transplantation.
[Journal of Molecular Histology] |
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| The authors review recently developed strategies for making 3D models of the human embryo built from ESCs, which they refer to as embryoids.
[Seminars in Cell & Developmental Biology] |
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| Two of Yale’s stem cell faculty — Drs. Haifan Lin, and Valentina Greco — are serving in the highest ranks of the International Society for Stem Cell Research.
[Yale School of Medicine] |
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| September 27 – 29, 2022
Leuven, Belgium |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Human Technopole – Milano, Italy |
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| | Institute for Cell Engineering – Baltimore, Maryland, United States |
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| | US Department of Health and Human Services – Research Triangle Park, North Carolina, United States |
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| | Weill Cornell Medical College – New York, New York, United States |
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