 | | Vol. 17.30 – 3 August, 2022 |
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| Researchers adapted a recently established platform for prolonged ex utero growth of natural embryos to generate mouse post-gastrulation synthetic whole embryo models.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists generated a panel of airway epithelial cells using iPSCs from individuals with common or rare cystic fibrosis transmembrane conductance regulator (CFTR) variants representative of three distinct classes of CFTR dysfunction.
[Nature Communications] |
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| To accelerate neuron production, an acoustic stimulator producing surface acoustic waves was proposed and realized by clamping a flexible printed circuit board directly onto a piezoelectric substrate.
[Acta Biomaterialia] |
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| Investigators tested different combinations of off-target reduction methods to further diminish off-target effects of adenine base editors without compromising their on-target editing efficiencies.
[Molecular Therapy-Nucleic Acids] |
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| The authors found that their accelerated 12-day method for the differentiation of podocytes from hiPSCs yielded podocytes with comparable marker expression to longer podocytes.
[Stem Cell Research & Therapy] |
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| Scientists knocked out Itgb1 in mouse iPSCs and evaluated its effects on the therapeutic potential of topically applied iPSCs, as well as their underlying in vivo and in vitro mechanisms.
[Stem Cell Research & Therapy] |
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| Investigators found that, compared with 2iL-derived mESCs, protein kinase C-derived mESCs showed low mRNA expression of nucleosome remodeling and deacetylase complex subunits, including MBD3, HDAC1/HDAC2, MTA1, and RbAP46/RbAP48.
[Cell Death Discovery] |
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| The authors developed a method for generating murine kidney organoids with improved higher-order structure, through stages using chimaeras of ex-fetu and PSC-derived cells to a system that worked entirely from ESCs.
[Scientific Reports] |
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| Researchers identified an unprecedented functional connection between Rif1 and the non-canonical polycomb repressive complex PRC1.6. Downregulation of the expression of either Rif1 or PRC1.6 subunits imposed similar impacts on the transcriptome of mESCs.
[Cell Regeneration] |
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| Recent studies of cultured mPSCs have clarified the presence of intermediate pluripotent stages between the naïve pluripotent state represented by ESCs and the primed pluripotent state represented by epiblast stem cells.
[EMBO Reports] |
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| The authors review the current state of technology in stem cell-based modeling of the central nervous system and how these models can be used to determine viral tropism and identify cellular phenotypes to investigate virus-host interactions and facilitate drug screening.
[Frontiers in Virology] |
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| Clarkson University Biology Professor Dr. Kenneth Wallace was recently awarded a $429,000 grant from the National Institute of Health (NIH) to investigate the development of intestinal stem cells using the zebrafish vertebrate model system.
[Clarkson University] |
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| September 27 – 29, 2022
Leuven, Belgium |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Human Technopole – Milano, Italy |
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| | US Department of Health and Human Services – Research Triangle Park, North Carolina, United States |
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