ESC & iPSC News Volume 17.34 | Aug 16 2023

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    2023-08-17 | ESC 18.31


    ESC & iPSC News by STEMCELL Technologies
    Vol. 17.34 – 16 August, 2023
    TOP STORY

    Fluorescent Protein Lifetimes Report Densities and Phases of Nuclear Condensates During Embryonic Stem-Cell Differentiation

    Investigators showed that a reduction in fluorescence lifetimes of common monomeric fluorescent proteins reported increased levels of local densities.
    [Nature Communications]

    Full Article
    The complex genettics of schizophrenia are unclear. So she developed a new approach.
    PUBLICATIONSRanked by the impact factor of the journal

    Patient-Specific iPSC-Derived Cardiomyocytes Reveal Variable Phenotypic Severity of Brugada Syndrome

    26 iPSC lines were generated from skin fibroblasts using nonintegrated Sendai virus. The generated iPSCs were differentiated into cardiomyocytes using a monolayer-based differentiation protocol.
    [eBioMedicine]

    Full Article

    Single-Cell RNA-Seq Analysis of a Human Embryonic Stem Cell to Endothelial Cell System Based on Transcription Factor Overexpression

    The high-efficiency human ESC-endothelial cell induction system was established in a previous study. Scientists applied single-cell RNA sequencing of the differentiated cells at different time points and investigated the gene expression profiles.
    [Stem Cell Reviews and Reports]

    AbstractGraphical Abstract

    Utilizing Human Induced Pluripotent Stem Cells to Study Atrial Arrhythmias in the Short QT Syndrome

    To generate a unique model to study short QT syndrome-related atrial arrhythmias by combining the use of patient-specific human induced PSCs, atrial-specific differentiation schemes, two-dimensional tissue modeling, optical mapping, and drug testing.
    [Journal Of Molecular And Cellular Cardiology]

    Full Article

    The MORC2 p.S87L Mutation Reduces Proliferation of Pluripotent Stem Cells Derived from a Patient with the Spinal Muscular Atrophy-Like Phenotype by Inhibiting Proliferation-Related Signaling Pathways

    Investigators first constructed iPSCs with stable anti-Mesothelin-CAR expression and subsequently differentiated these cells into mesothelin-targeted CAR-NK cells.
    [Journal Of Immunotherapy]

    Abstract

    Modeling of Pigmentation Disorders Associated with MITF Mutation in Waardenburg Syndrome Revealed an Impaired Melanogenesis Pathway in iPS-Derived Melanocytes

    Scientists used induced pluripotent stem cells derived from a Waardenburg Syndrome (WS) patient carrying a heterozygous mutation in the MITF gene c.626A>T, and differentiated toward melanocyte lineage, which is the most affected cell type involved in WS.
    [Pigment Cell & Melanoma Research]

    Abstract

    Low-Dose Radiation Induces Unstable Gene Expression in Developing Human iPSC-Derived Retinal Ganglion Organoids

    Investigators analyzed the gene expression characteristics of neuronal organoids containing immature human retinal cells under low-dose radiation and predicted their changes.
    [Scientific Reports]

    Full Article

    Equine Induced Pluripotent Stem Cells Are Responsive to Inflammatory Cytokines before and after Differentiation into Musculoskeletal Cell Types

    Researchers determined if equine iPSCs were responsive to the inflammatory cytokines IL-1β, TNFα, and IFN-γ in their undifferentiated state, or following differentiation into tendon and cartilage-like cells.
    [In Vitro Cellular & Developmental Biology – Animal]

    Full Article

    Generation of the Human iPSC Lines AKOSi011-A Carrying the Mutation p.Pro65Ser/p.Asp35T and AKOSi012-A, Carrying the Mutation p.Tyr231His, Derived from FAHN Patient Fibroblasts

    Scientists described the generation of the hiPSC lines AKOSi011-A and AKOSi012-A, derived from fatty acid hydroxylase-associated neurodegeneration-patient fibroblasts, carrying the compound heterozygous mutation p.Pro65Ser/p.Asp35Tyr and the homozygous mutation p.Tyr231His, respectively.
    [Stem Cell Research]

    Full Article
    View tips on how to organize your lab notebooks, references and protocols.
    REVIEWS

    Reprogramming iPSCs to Study Age-Related Diseases: Models, Therapeutics, and Clinical Trials

    The authors discuss the advances made in the last decade using iPSC technology to study the most common age-associated diseases, including age-related macular degeneration, neurodegenerative and cardiovascular diseases, brain stroke, cancer, diabetes, and osteoarthritis.
    [Mechanisms Of Ageing And Development]

    Abstract
    INDUSTRY AND POLICY NEWS

    Therapeutic Solutions International Subsidiary Allogen Biologics Inc. Successfully Manufactures JadiCell Master Cell Bank to Provide Cells for Right to Try Use and Phase III ARDS Clinical Trial

    Therapeutic Solutions International, Inc. reported successful generation of a quality control tested Master Cell Bank comprised of its JadiCell universal donor stem cell product.
    [Therapeutic Solutions International, Inc. (BusinessWire, Inc.)]

    Full Article
    FEATURED EVENT

    Immunity and Aging

    October 1 – 4, 2023
    Whistler, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Faculty Position – Neurodegenerative Science

    Van Andel Institute – Grand Rapids, Michigan, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Postdoctoral Position – Engineering of iPSC-NK cells

    Technical University of Denmark – Kongens Lyngby, Denmark

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    Postdoctoral Scientist – Stem Cells & Liver Disorders

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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