 | | Vol. 17.34 – 7 September, 2022 |
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| Scientists described the tissue engineering of human thymus organoids from inducible PSCs that could support the de novo generation of a diverse population of functional human T cells.
[Nature Methods] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators discovered that naive hPSCs were competent to differentiate into extraembryonic mesoderm cells.
[Cell Stem Cell] |
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| Scientists modeled human heart field development from hPSCs by using single-cell RNA-sequencing to delineate lineage specification and progression.
[Cell Stem Cell] |
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| Researchers presented a spatial and temporal survey of the molecular dynamics of cell types populating the non-human primate embryos during gastrulation.
[Cell Reports] |
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| Comparing down syndrome and fragile X syndrome hPSC and glutamatergic neuron models, investigators identified increased protein expression of select targets and overlapping transcriptional perturbations.
[Cell Reports] |
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| The authors isolated exosomes from hESCs, hiPSCs, and human umbilical cord mesenchymal stem cells via classic ultracentrifugation and a 0.22-μm filter, followed by the conservative identification.
[Stem Cell Research & Therapy] |
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| Investigators generated iPSC lines from subjects with leukodystrophy, from parents of the complex heterozygous mutations patient, and from CRISPR isogenic corrected iPSC-line.
[Stem Cell Research] |
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| Researchers described a stepwise protocol for differentiation of the hiPSC line into the islet-like cluster using several growth factors and small molecules.
[Gene] |
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| Scientists developed modified mRNA (modRNA)-based CRIPSR systems that utilized Cas9 and p53DD or a base editor modRNA for the purposes of knocking out genes in hPSCs via simple lipid-based transfection.
[Cell Reports Methods] |
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| The authors review progress made over the past decade in the generation and use of stem cell-derived metabolic cell types and organoids in metabolic disease research, especially obesity and liver diseases.
[Nature Reviews Endocrinology] |
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| Scientists summarize the available state of knowledge surrounding the physiological mechanisms underlying cell maturation in several key tissues.
[NPJ Regenerative Medicine] |
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| At the National Institutes of Health, a surgical team successfully implanted a patch of tissue made from patient cells with the goal of treating advanced “dry” age-related macular degeneration (AMD), also known as geographic atrophy.
[National Institutes of Health] |
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| December 5 – 7, 2022
Virtual |
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| | Lewis Katz School of Medicine, Temple University – Philadelphia, Pennsylvania, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Helmholtz Munich – Neuherberg, Germany |
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| | University of Gothenburg – Gothenburg, Sweden |
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