ESC & iPSC News Volume 17.35 | Sep 14 2022

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    2022-09-14 | ESC 17.35


    ESC & iPSC News by STEMCELL Technologies
    Vol. 17.35 – 14 September, 2022
    TOP STORY

    Mouse Embryo Model Derived Exclusively from Embryonic Stem Cells Undergoes Neurulation and Heart Development

    Scientists have developed a mouse ESC-based in vitro model that reconstituted the pluripotent ESC lineage and the two extraembryonic lineages of the post-implantation embryo by transcription-factor-mediated induction.
    [Cell Stem Cell]

    Full ArticlePress ReleaseGraphical Abstract
    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Stem Cell-Derived Synthetic Embryos Self-Assemble by Exploiting Cadherin Codes and Cortical Tension

    The authors showed that a stem cell-specific cadherin code drove synthetic embryogenesis.
    [Nature Cell Biology]

    Full Article

    Dynamic Gelatin-Based Hydrogels Promote the Proliferation and Self-Renewal of Embryonic Stem Cells in Long-Term 3D Culture

    Gelatin-based structurally dynamic hydrogels significantly promoted the clonal expansion and viability of encapsulated mESCs independent of MMP-mediated hydrogel degradation.
    [Biomaterials]

    Full Article

    Myogenesis Defects in a Patient-Derived iPSC Model of Hereditary GNE Myopathy

    Investigators aimed to address this knowledge gap by querying the underlying mechanisms of UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy using a patient-derived iPSC model.
    [NPJ Regenerative Medicine]

    Full Article

    Heparinized Gelatin-Based Hydrogels for Differentiation of Induced Pluripotent Stem Cells

    Scientists exploited the modularity of thiol-norbornene photopolymerization to create a biomimetic hydrogel platform for 3D culture and differentiation of hiPSCs.
    [Biomacromolecules]

    Full Article

    Long Noncoding RNA Lx8-SINE B2 Interacts with Eno1 to Regulate Self-Renewal and Metabolism of Embryonic Stem Cells

    Depletion of Lx8-SINE B2 disrupted ESC proliferation, repressed the expression of pluripotency genes, activated differentiation genes, and inhibited reprogramming to iPSCs.
    [Stem Cells]

    AbstractGraphical Abstract

    Acquisition and Maintenance of Pluripotency Are Influenced by Fibroblast Growth Factor, Leukemia Inhibitory Factor, and 2i in Bovine-Induced Pluripotent Stem Cells

    Investigators reprogrammed fetal fibroblasts by transient expression of the four transcription factors and cultured in iPSC medium, and then compared these bovine iPSC lines with bovine ESC to evaluate the pluripotent state.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    Zbtb34 Promotes Embryonic Stem Cell Proliferation by Elongating Telomere Length

    The upregulation of Zbtb34 in mESCs promoted telomere elongation and increased cell proliferation.
    [Aging-Us]

    Full Article

    Trim28 Citrullination Maintains Mouse Embryonic Stem Cell Pluripotency via Regulating Nanog and Klf4 Transcription

    Investigators showed that tripartite motif containing 28 (Trim28) was specifically citrullinated in mESCs, and that the loss of Trim28 citrullination induced loss of pluripotency.
    [Science China Life Sciences]

    Abstract

    Dual Genome-Wide Coding and lncRNA Screens in Neural Induction of Induced Pluripotent Stem Cells

    Using CRISPR interference in hiPSCs, researchers performed dual genome-wide screens—assessing 18,905 protein-coding and 10,678 lncRNA loci—and identified 419 coding and 201 lncRNA genes that regulate neural induction.
    [Cell Genomics]

    Full ArticleGraphical Abstract
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Recent Advances for Using Human Induced-Pluripotent Stem Cells as Pain-in-a-Dish Models of Neuropathic Pain

    The authors review recent developments in differentiating iPSC-derived sensory neurons and their use in pre-clinical translational studies.
    [Experimental Neurology]

    Abstract
    INDUSTRY AND POLICY NEWS

    UC San Diego Joins NIH ‘Bridge to Artificial Intelligence’ Program

    Researchers at the University of California (UC) San Diego School of Medicine have been selected to lead components of the National Institutes of Health (NIH) Common Fund’s Bridge to Artificial Intelligence ‘Bridge2AI’ program.
    [UC San Diego]

    Press Release
    FEATURED EVENT

    Diet, Nutrition and Cancer Cell Metabolism

    October 24 – 26, 2022
    Madrid, Spain

    > See All Events

    JOB OPPORTUNITIES

    PhD Position – Molecular Cell Biology & Genome Editing

    Leiden University Medical Center – Leiden, Netherlands

    Assistant Professor – Stem Cell Biology

    University of California Santa Cruz – Santa Cruz, California, United States

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral/Research Scientist – CRISPR/Cas Genome Editors

    Lewis Katz School of Medicine, Temple University – Philadelphia, Pennsylvania, United States

    PhD Fellowship – Gene Therapy

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    > See All Jobs

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