 | | Vol. 17.36 – 21 September, 2022 |
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| Scientists showed that imprinting defects were remarkably common in iPSCs, but their nature depended on the sex of donor cells and their response to culture conditions.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Employing quantitative mass spectrometry during hESC differentiation, investigators identified dozens of ribosome composition changes underlying cell fate specification.
[Nature Communications] |
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| Researchers transplanted the xeno-free-induced MSCs into mouse models for bone and skeletal muscle regeneration and confirmed their regenerative potency.
[NPJ Regenerative Medicine] |
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| The effects of integrase inhibitors on two hESC lines were characterized with respect to markers of pluripotency, early differentiation, and cellular health.
[Journal of infectious Diseases] |
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| The authors revealed that the hESCs cultured in both conditions maintained the expression of stemness markers and the ability to spontaneously differentiate into the three germ layers.
[Aging-Us] |
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| Scientists presented evidence that overexpression of SOX10 and OLIG2 in hESCs derived ventral forebrain neural progenitors was sufficient to produce forebrain pre-oligodendrocytes (OLs) and mature OLs within 20-40 days.
[iScience] |
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| Investigators identified fibroblast growth factor signaling in feeder-free PSC maintenance as a key factor that determined the differentiation toward cerebral organoids.
[iScience] |
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| Researchers generated good manufacturing practice-compatible neural progenitor cells from transgene- and xeno-free induced pluripotent stem cells that can be smoothly adapted for clinical applications.
[Journal of Translational Medicine] |
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| Scientists examined the effect of perfluorooctanesulfonic acid (PFOS) on cardiomyocyte differentiation by transcriptomics profiling of two different hiPSC lines to see if they exhibited a common pattern of disruption.
[Toxicology in Vitro] |
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| The authors described the experimental strategy for generating knockout and knockin clonal populations of hiPSCs using single-cell sorting by flow cytometry.
[STAR Protocols] |
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| Investigators presented a protocol to perform a CRISPR-Cas9 screen in hESCs to identify regulators that promoted SOX1 expression during neural progenitor cell formation.
[STAR Protocols] |
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| Scientists summarize what is known about the role of methyltransferase-like (METTL) proteins in stem cell differentiation and their established roles in oncogenesis.
[Stem Cell Reviews and Reports] |
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| In the spring of 2013, around 180 scientists who had recently published computational studies in Science received an email from a Columbia University student asking for the code underpinning those pieces of research.
[The Scientist] |
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| November 6 – 8, 2022
Seville, Spain |
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| | Syracuse University – Syracuse, New York, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Leiden University Medical Center – Leiden, Netherlands |
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| | University of California Santa Cruz – Santa Cruz, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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