 | | Vol. 17.37 – 28 September, 2022 |
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| Scientists showed that conditional knock-out of Setdb1 in mouse embryonic endoderm resulted in endogenous retrovirus de-repression in visceral endoderm descendants and did not occur in definitive endoderm.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By coupling evolutionary sequence analysis with functional studies in mESCs, investigators found that the ability of POU5 proteins to support pluripotency originated in the gnathostome lineage, prior to the generation of two paralogues, Pou5f1 and Pou5f3 via gene duplication.
[Nature Communications] |
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| The authors studied the immediate, genome-wide consequences of the H3.3K27M mutation independent of Polycomb Repressor Complex 2 (PRC2) activity. They developed Doxycycline-inducible mouse ESCs carrying a single extra copy of WT-H3.3, H3.3K27M, and H3.3K27L all fused to HA.
[Nucleic Acids Research] |
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| Scientists showed that the Nodal induced lncRNA-Smad7 regulated cell fate determination via repression of BMP signaling in mESCs.
[Nucleic Acids Research] |
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| The authors induced mesenchymal stem cells from hiPSCs via a neural crest cell lineage under xeno-free conditions and evaluated their in vivo functions.
[NPJ Regenerative Medicine] |
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| Downregulation, deletion, or inhibition of PIM3 activated MuERVL, 2-cell genes, and trophectodermal genes in ESCs. By screening PIM3-regulated pathways, scientists discovered AMPK as its key target.
[Stem Cell Reports] |
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| The authors investigated the molecular effects of acute and prolonged hypoxia on embryonic and extra-ESCs as well as the functional impact on differentiation potential.
[Development] |
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| Researchers systematically compared five different retinal pigment epithelial purification methods, including manual, enzymatic, flow cytometry-based sorting or combinations thereof for parameters including cell throughput, yield, purity and functionality.
[Scientific Reports] |
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| Scientists investigated the effect of passage number on iPSC differentiation to optimize the generation of sensory neurons (iPSC-dSNs). Three iPSC lines reprogrammed from the peripheral blood of three donors were differentiated into iPSC-dSNs at passage numbers within each of the following ranges: 5–10, 20–26, and 30–38.
[Scientific Reports] |
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| Investigators showed that CCCTC-binding factor (CTCF) could be acetylated at lysine 20 (CTCF-K20) by CREB-binding protein (CBP) and deacetylated by histone deacetylase 6 (HDAC6). CTCF-K20 was required for the CTCF interaction with CBP.
[Cell Regeneration] |
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| The authors merged the strengths of different classes of site-specific recombinases and combined these with CRISPR-Cas9-mediated homologous recombination to develop a strategy for stringent site-specific replacement of genomic fragments at least 50 kb in size in hiPSCs.
[Cell Reports Methods] |
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| Investigators summarize the progress made thus far in generating 2D and 3D iPSCs models for urea cycle disorders (UCDs), the challenges encountered, and how iPSCs offer future avenues for innovation in developing the next-generation of therapies for UCDs.
[NPJ Regenerative Medicine] |
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| Scientists provide a brief background on Alzheimer’s disease (AD) in the context of APOE susceptibility and feature work employing hiPSC-derived brain cell and tissue models to interrogate the contribution of APOE in driving AD pathology.
[Life Science Alliance] |
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| The University of Manchester will collaborate with several Indian institutes, medical research centers and corporates to boost initiatives to find solutions to global problems. In Bengaluru, the delegation will visit the National Centre for Biological Sciences to build on links in areas such as stem cell research.
[University of Manchester (Education Times)] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | NIH – Research Triangle Park, North Carolina, United States |
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| | InVitro Cell Research, LLC – Fort Lee, New Jersey, United States |
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| | Syracuse University – Syracuse, New York, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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