 | | Vol. 17.41 – 26 October, 2022 |
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| Investigators showed that acute deletion of all three Tet genes, after brief exposure of triple-floxed, Cre-ERT2-expressing mESCs to 4-hydroxytamoxifen, resulted in chromosome missegregation and aneuploidy.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers presented a CRISPR/Cas9-mediated ABO gene edition strategy for the conversion of blood type A to universal type O, which they had applied to an Rhnull donor-derived hiPSC line, originally carrying blood group A.
[Clinical and Translational Medicine] |
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| In the absence of WNT stimulation, transforming growth factor β pathway inhibition led to direct and robust conversion of primed human PSCs into trophoblast stem cells.
[Stem Cell Reports] |
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| The authors generated two PITX2 knock-out human iPSC lines using CRISPR/Cas9 genome editing. The edited iPSCs maintained full pluripotency, normal karyotype, and spontaneous differentiation capability.
[Stem Cell Research] |
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| Researchers developed two hiPSC lines using CRISPR/Cas9-mediated allele-specific frame-shift deletion of the aSyn encoding gene SNCA, resulting in homo- and heterozygous SNCA knockout.
[Stem Cell Research] |
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| Investigators generated iPSCs from the last male Malaysian Sumatran rhino Kertam, who died in 2019, and characterized them comprehensively.
[iScience] |
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| Scientists established novel iPSCs from three endangered avian species with seven reprogramming factors.
[Communications Biology] |
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| Researchers used transcriptomics to interrogate the process by which pluripotent cells transit to four different lineage-restricted states: neural progenitors, epidermis, endoderm, and ventral mesoderm.
[BMC Genomics] |
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| Investigators applied cutting-edge technologies to analyze the transcriptomic and epigenomic landscape of bovine ESC obtained from in vitro fertilized and somatic cell nuclear transfer embryos.
[Reproduction] |
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| The authors suggest that iPSCs and gene-editing techniques can play a pivotal role in elucidating the mechanisms of gene-environment interactions and understanding individual variability in susceptibility to environmental effects.
[EMBO Molecular Medicine] |
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| Scientists examine the events driving pluripotent stem cell fate and the underlying changes in gene expression during early development.
[Experimental & Molecular Medicine] |
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| New international collaboration between scientists in Canada and Japan aims to accelerate therapies for cancer and other diseases using precisely engineered cells from the patient’s own body.
[National Research Council Canada] |
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| April 23 – 28, 2023
Cancun, Mexico |
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| | Harvard University – Boston, Massachusetts, United States |
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| | King’s College London – London, England, United Kingdom |
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| | Kunming University of Science and Technology – Kunming, China |
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| | University of Maryland School of Medicine – Baltimore, Maryland, United States |
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| | Max Delbrück Center for Molecular Medicine (MDC) – Berlin, Germany |
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