 | | Vol. 17.42 – 2 November, 2022 |
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| Researchers identified the cytoskeletal linker protein desmoplakin as a common factor mediating both in vitro reprogramming and in vivo regeneration.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To test whether KRAB-zinc finger proteins could regulate cell fate by using ZFP819, investigators found that depleting ZFP819 in mESCs caused them to transition to a 2-cell-like state, whereby the ZP3AR array switched from a poised to an active enhancer state.
[Science Advances] |
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| Scientists reported that co-delivery of p53DD, a dominant negative fragment of p53, could greatly enhance prime editing (PE) and cytosine base editing efficiencies in generating precise mutations in hPSCs. They further applied PE3 enzyme in combination with p53DD to efficiently create multiple isogenic hPSC lines.
[Nature Communications] |
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| RNA sequencing and lineage fate analysis revealed that budesonide prevented ESC aggregates to break symmetry by counteracting exit from pluripotency and modifying the expression of a large set of genes associated with cell migration, A-P axis formation, and WNT signaling.
[Stem Cell Reports] |
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| Researchers established a fast and efficient induction system of porcine iPSCs from porcine Sertoli cells via forced expression of pig Yamanaka factors.
[Journal of Cellular Physiology] |
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| The authors focused on identifying markers for iPSC impurities in iPSC-derived cardiomyocytes and validated the selected genes by reverse transcription quantitative polymerase chain reaction.
[Cytotherapy] |
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| Using a novel coarse-grained model and molecular dynamics simulations, scientists probed the association of Sox2 and Oct4 proteins that showed clustered binding at the entry-exit region of a nucleosome.
[Biophysical Journal] |
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| Green fluorescent protein+/iPS‑like colony generation was facilitated by the small molecules CHIR99021 and RepSox during lentivirus‑mediated reprogramming of six transcription factors in rat embryonic fibroblasts.
[International Journal of Molecular Medicine] |
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| Investigators used three types of DNA methyltransferase (Dnmt) knockout (KO) ESCs, including Dnmt1 KO, Dnmt3a/3b double KO, and Dnmt1/3a/3b triple KO, to investigate the role of Dnmts in neural differentiation of ESCs.
[International Journal of Stem Cells] |
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| The authors review the state of the art of use of PSCs as a model for hematopoietic and leukemia development.
[Stem Cells Translational Medicine] |
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| I Peace, Inc. announced that the company has agreed to join the California Institute for Regenerative Medicine’s (CIRM) Industry Resource Partner Program to pave way for the provision of Good Manufacturing Practice iPSCs for various research programs funded by CIRM.
[I Peace, Inc. (Cision US Inc.)] |
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| Cedars-Sinai has been awarded a five-year, $8 million grant from California’s stem cell agency to launch an innovative new clinic that will expand patients’ access to stem cell and gene therapies.
[Cedars-Sinai] |
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| March 6 – 8, 2023
Paris, France |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | NIH National Center for Advancing Translational Sciences – Rockville, Maryland, United States |
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| | Cold Spring Harbor Laboratory – New York, New York, United States |
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| | DaCapo Brainscience – Cambridge, Massachusetts, United States |
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